Effects of the fermentation process on the selenite metabolism and selenium incorporation and speciation in a probiotic Bifidobacterium longum

被引：1
作者：
Zhu, Hui [1 ,2 ]
Bierla, Katarzyna [2 ]
Tan, Jun [3 ,5 ]
Szpunar, Joanna [2 ]
Chen, Daijie [1 ]
Lobinski, Ryszard [2 ,4 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Pharm, State Key Lab Microbial Metab, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
[2] Univ Pau & Pays Adour, Inst Analyt & Phys Chem Environm & Mat, CNRS, E2S,IPREM,UMR5254, F-64053 Pau, France
[3] China State Inst Pharmaceut Ind, Pudong New Area, 285 Gebaini Rd, Shanghai 200120, Peoples R China
[4] Warsaw Univ Technol, Chair Analyt Chem, PL-00664 Warsaw, Poland
[5] China State Inst Pharmaceut Ind, Dept Biopharmaceut, Pudong New Area, 285 Gebaini Rd, Shanghai 200120, Peoples R China
来源：
METALLOMICS | 2023年 / 15卷 / 01期
关键词：
Bifidobacterium longum; selenium; fermentation; selenomethionine; gamma-glutamyl-selenomethionine; HPLC-ICP MS; LACTIC-ACID BACTERIA; GROWTH; YEAST;
D O I：
10.1093/mtomcs/mfac100
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The influence of the fermentation process on selenite metabolism by a probiotic Bifidobacterium longum DD98 and its consequent enrichment in selenium (Se) were studied. The effects of sodium selenite (Na2SeO3) concentration (18-400 mu g/ml), feeding time (12, 16, and 24 h), and fermentation stage (secondary and tertiary fermentation) were evaluated by measuring (i) the total Se content and its distribution between the water-soluble metabolome fraction and the water-insoluble fraction; (ii) the total concentrations of the two principal Se compounds produced: selenomethionine (SeMet) and gamma-glutamyl-selenomethionine (gamma-Glu-SeMet), and (iii) the speciation of Se in the metabolite fraction. The results revealed that the fermentation process notably changed the Se incorporation into metabolites (gamma-Glu-SeMet and free SeMet) and proteins (bound-SeMet) in B. longum DD98. In particular, the production of SeMet was negatively correlated to that of gamma-Glu-SeMet when no red precipitate was seen in the bacteria. The study offers a tool for the control of the optimization of the fermentation process towards the desired molecular speciation of the incorporated Se and hence contributes to the production of Se-enriched probiotics with good qualities and bioactivities.
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页数：11
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