Effectiveness and Duration of Protection of a Fourth Dose of Coronavirus Disease 2019 Messenger RNA Vaccine Among Long-term Care Residents in Ontario, Canada

被引：8

作者：

Grewal, Ramandip ^{[1
]}

Nguyen, Lena ^{[2
]}

Buchan, Sarah A. ^{[1
,2
,3
,4
]}

Wilson, Sarah E. ^{[1
,2
,3
,4
]}

Costa, Andrew P. ^{[5
,6
,7
]}

Kwong, Jeffrey C. ^{[1
,2
,3
,4
,8
,9
,10
]}

机构：

[1] Publ Hlth Ontario, Toronto, ON, Canada

[2] ICES, Toronto, ON, Canada

[3] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[4] Univ Toronto, Ctr Vaccine Preventable Dis, Toronto, ON, Canada

[5] McMaster Univ, Michael G DeGroote Sch Med, Dept Med, Hamilton, ON, Canada

[6] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada

[7] St Josephs Hlth Syst, Ctr Integrated Care, Hamilton, ON, Canada

[8] Univ Toronto, Dept Family & Community Med, Toronto, ON, Canada

[9] Univ Hlth Network, Toronto, ON, Canada

[10] G1 06,2075 Bayview Ave, Toronto, ON M4N 3M5, Canada

来源：

JOURNAL OF INFECTIOUS DISEASES | 2023年 / 227卷 / 08期

关键词：

COVID-19; duration of protection; fourth doses; long-term care residents; marginal effectiveness; vaccine effectiveness;

D O I：

10.1093/infdis/jiac468

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We estimated the effectiveness of a fourth dose of messenger RNA coronavirus disease 2019 vaccine against Omicron infections and severe outcomes over time among long-term care residents in Ontario, Canada. Fourth doses provide additional protection against Omicron-related outcomes, but the protection wanes over time, with more waning seen against infection than severe outcomes.

引用

页码：977 / 980

页数：4

共 8 条

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BMJ-BRITISH MEDICAL JOURNAL, 2022, 378

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