Syntheses of Linear Biosynthetic C25-Precursors of Leucosceptroids

被引：1
作者：
Li, Tao [1 ,2 ]
Li, Hao [1 ,2 ]
Zhou, Ting-Ting [3 ,4 ]
Zheng, Yu [3 ]
Li, Sheng-Hong [1 ,2 ,3 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Sichuan, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Sichuan, Peoples R China
[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Chi, Kunming 650201, Yunnan, Peoples R China
[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 05期
基金：
中国国家自然科学基金;
关键词：
CANUM;
D O I：
10.1021/acs.joc.3c02796
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthetic approach was developed and applied to the syntheses of four linear biosynthetic C-25-precursors of leucosceptroids. The synthesis features a Julia-Kocienski olefination and a late-stage bioinspired photo-oxidation as key steps. The immunosuppressive effects of all synthetic compounds on mouse T cells and macrophage RAW264.7 were determined.
引用
收藏
页码：3652 / 3656
页数：5
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