Towards new antibiotics classes targeting bacterial metallophores

被引：39

作者：

Ezzeddine, Zeinab ^{[1
]}

Ghssein, Ghassan ^{[1
]}

机构：

[1] Islamic Univ Lebanon IUL, Fac Publ Hlth, Lab Sci Dept, POB 30014, Khalde, Lebanon

来源：

MICROBIAL PATHOGENESIS | 2023年 / 182卷

关键词：

Infectious diseases; Antimicrobial therapy; Metallophores; Bacterial resistance; SIDEROPHORE; MECHANISMS;

D O I：

10.1016/j.micpath.2023.106221

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The increasing bacterial resistance caused by antibiotic overuse has promoted the search for new antimicrobial strategies. Metals uptake via bacterial metallophores are studied to develop new therapeutics against infectious diseases, because metal ions are essential for bacterial growth and virulence. Metal ions assimilation is mainly dependent on metallophores production which are metal chelators synthetized and produced by bacteria to facilitate metals uptake and are vital for bacterial pathogenicity. Here we highlight the perspective for antimicrobial and therapeutic potential of metallophores through several approaches for metallophores application in antimicrobial therapy.

引用

页数：3

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