Prognostic Value of Inflammatory Bowel Disease-associated Biomarkers in Patients With Immune Checkpoint Inhibitor Enterocolitis: A Retrospective Cohort Study

被引：1

作者：

Kogan, Lawrence ^{[1
]}

Townsend, Matthew J. ^{[2
]}

Raj, Dhanya ^{[3
]}

Levy, Alexander N. ^{[4
]}

Giobbie-Hurder, Anita ^{[5
]}

Grover, Shilpa ^{[3
,6
,7
]}

机构：

[1] Yale Sch Med, Div Digest Dis, New Haven, CT USA

[2] Duke Univ, Med Ctr, Dept Med, Durham, NC USA

[3] Brigham & Womens Hosp, Div Gastroenterol Hepatol & Endoscopy, Boston, MA USA

[4] Tufts Med Ctr, Div Gastroenterol, Boston, MA USA

[5] Dana Farber Canc Inst, Dept Data Sci, Div Biostat, Boston, MA USA

[6] Harvard Med Sch, Boston, MA USA

[7] Brigham & Womens Hosp, Onco Gastroenterol Program, Div Gastroenterol Hepatol & Endoscopy, 75 Francis St, Boston, MA 02115 USA

来源：

INFLAMMATORY BOWEL DISEASES | 2024年 / 30卷 / 06期

关键词：

immune checkpoint inhibitor; immune-related adverse event; colitis; biologic; biomarker; CROHNS-DISEASE;

D O I：

10.1093/ibd/izad121

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Lay Summary In the emerging field of immune checkpoint inhibitor enterocolitis, biomarkers to predict disease course are lacking. Select genetic polymorphisms (ATG16L1(T300A)) and serum amyloid A warrant further study as potential biomarkers associated with severe ICI enterocolitis.

引用

页码：1032 / 1035

页数：4

共 10 条

[1] C-reactive protein as an early marker of immune-related adverse events [J].

Abolhassani, Amir-Reza ;

Schuler, Gerold ;

Kirchberger, Michael Constantin ;

Heinzerling, Lucie .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2019, 145 (10) :2625-2631

[2]

Berman David, 2010, Cancer Immun, V10, P11

[3] Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way? [J].

Cheung, Vincent Ting Fung ;

Gupta, Tarun ;

Olsson-Brown, Anna ;

Subramanian, Sreedhar ;

Sasson, Sarah Christina ;

Heseltine, Jonathan ;

Fryer, Eve ;

Collantes, Elena ;

Sacco, Joseph J. ;

Pirmohamed, Munir ;

Simmons, Alison ;

Klenerman, Paul ;

Tuthill, Mark ;

Protheroe, Andrew S. ;

Chitnis, Meenali ;

Fairfax, Benjamin Peter ;

Payne, Miranda Jane ;

Middleton, Mark Ross ;

Brain, Oliver .

BRITISH JOURNAL OF CANCER, 2020, 123 (02) :207-215

[4] The Crohn Disease-associated ATG16L1T300A polymorphism regulates inflammatory responses by modulating TLR- and NLR-mediated signaling [J].

Gao, Ping ;

Liu, Hongtao ;

Huang, Huarong ;

Sun, Yu ;

Jia, Baoqian ;

Hou, Baidong ;

Zhou, Xuyu ;

Strober, Warren ;

Zhang, Fuping .

AUTOPHAGY, 2022, 18 (11) :2561-2575

[5] Biomarkers of Checkpoint Inhibitor Induced Immune-Related Adverse Events-A Comprehensive Review [J].

Hommes, Josefien W. ;

Verheijden, Rik J. ;

Suijkerbuijk, Karijn P. M. ;

Hamann, Dorte .

FRONTIERS IN ONCOLOGY, 2021, 10

[6] Cancer Immunotherapy with Anti-CTLA-4 Monoclonal Antibodies Induces an Inflammatory Bowel Disease [J].

Marthey, L. ;

Mateus, C. ;

Mussini, C. ;

Nachury, M. ;

Nancey, S. ;

Grange, F. ;

Zallot, C. ;

Peyrin-Biroulet, L. ;

Rahier, J. F. ;

de Beauregard, M. Bourdier ;

Mortier, L. ;

Coutzac, C. ;

Soularue, E. ;

Lanoy, E. ;

Kapel, N. ;

Planchard, D. ;

Chaput, N. ;

Robert, C. ;

Carbonnel, F. .

JOURNAL OF CROHNS & COLITIS, 2016, 10 (04) :395-401

[7] Combined Serological, Genetic, and Inflammatory Markers Differentiate Non-IBD, Crohn's Disease, and Ulcerative Colitis Patients [J].

Plevy, Scott ;

Silverberg, Mark S. ;

Lockton, Steve ;

Stockfisch, Tom ;

Croner, Lisa ;

Stachelski, Jordan ;

Brown, Michelle ;

Triggs, Cheryl ;

Chuang, Emil ;

Princen, Fred ;

Singh, Sharat .

INFLAMMATORY BOWEL DISEASES, 2013, 19 (06) :1139-1148

[8] Biomarkers of Crohn's Disease to Support the Development of New Therapeutic Interventions [J].

Porter, Amy C. ;

Aubrecht, Jiri ;

Birch, Chandler ;

Braun, Jonathan ;

Cuff, Carolyn ;

Dasgupta, Suryasarathi ;

Gale, Jeremy D. ;

Hinton, Robert ;

Hoffmann, Steven C. ;

Honig, Gerard ;

Linggi, Bryan ;

Schito, Marco ;

Vande Casteele, Niels ;

Sauer, John-Michael .

INFLAMMATORY BOWEL DISEASES, 2020, 26 (10) :1498-1508

[9] Immune Checkpoint Inhibitor-Associated Colitis: From Mechanism to Management [J].

Tang, Liansha ;

Wang, Jialing ;

Lin, Nan ;

Zhou, Yuwen ;

He, Wenbo ;

Liu, Jiyan ;

Ma, Xuelei .

FRONTIERS IN IMMUNOLOGY, 2021, 12

[10]

THOMAS A, 2022, CLIN GASTROENTEROL H, V21, P878, DOI DOI 10.1016/J.CGH.2022.10.004

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