Mechanic Insight into the Distinct and Common Roles of Ovariectomy Versus Adrenalectomy on Adipose Tissue Remodeling in Female Mice

被引:3
|
作者
Chen, Weihao [1 ]
Meng, Fengyan [1 ]
Zeng, Xianyin [1 ]
Cao, Xiaohan [1 ]
Bu, Guixian [1 ]
Du, Xiaogang [1 ]
Yu, Guozhi [1 ]
Kong, Fanli [1 ]
Li, Yunkun [1 ]
Gan, Tian [1 ]
Han, Xingfa [1 ]
机构
[1] Sichuan Agr Univ, Biol Engn & Applicat Biol Dept, Isotope Res Lab, Yaan 625014, Peoples R China
基金
中国国家自然科学基金; 英国科研创新办公室;
关键词
adipose tissue; remodeling; ovariectomy; adrenalectomy; transcriptomics; mice; FAT; ADIPOGENESIS; ESTROGEN; GLUCOCORTICOIDS; METABOLISM; SENESCENCE; PHENOTYPE; BIOLOGY;
D O I
10.3390/ijms24032308
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Dysfunctions of the ovaries and adrenal glands are both evidenced to cause aberrant adipose tissue (AT) remodeling and resultant metabolic disorders, but their distinct and common roles are poorly understood. In this study, through biochemical, histological and RNA-seq analyses, we comprehensively explored the mechanisms underpinning subcutaneous (SAT) and visceral adipose tissue (VAT) remodeling, in response to ovariectomy (OVX) versus adrenalectomy (ADX) in female mice. OVX promoted adipocyte differentiation and fat accumulation in both SAT and VAT, by potentiating the Pparg signaling, while ADX universally prevented the cell proliferation and extracellular matrix organization in both SAT and VAT, likely by inactivating the Nr3c1 signaling, thus causing lipoatrophy in females. ADX, but not OVX, exerted great effects on the intrinsic difference between SAT and VAT. Specifically, ADX reversed a large cluster of genes differentially expressed between SAT and VAT, by activating 12 key transcription factors, and thereby caused senescent cell accumulation, massive B cell infiltration and the development of selective inflammatory response in SAT. Commonly, both OVX and ADX enhance circadian rhythmicity in VAT, and impair cell proliferation, neurogenesis, tissue morphogenesis, as well as extracellular matrix organization in SAT, thus causing dysfunction of adipose tissues and concomitant metabolic disorders.
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页数:25
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