Reliability and stability of oddball P300 amplitude in older adults: The role of stimulus sequence effects

The P300 may be an individual difference marker of neuro-cognitive function, which due to age-related cognitive decline may be particularly useful in older adults. Recently, we reported effects of the local stimulus sequence in an oddball task (i.e., the number of non-targets that preceded a target) on P300 amplitude in young and older adults. The same older adults completed a second session of the task 4-8 months after the first session. Here, we examined the effect of the stimulus sequence on the between-and within-session reliability and stability of P300 amplitude and RT, and their intertrial variability, in this sample of older adults. The sequence effects - an inverted U-shape effect of the number of standards preceding a target on parietal P300, and a linear effect on frontal P300 -were stable within and across sessions on the group level. Within individuals, P300 amplitude at frontal and parietal electrodes was generally very reliable and stable, mostly independently of sequence effects, encouraging its use as an individual difference marker of neuro-cognitive function in older adults. However, measures of the strength of the sequence effects themselves showed unacceptable reliability, speaking against their use as individual difference markers, at least in older adults.