Spectrum From Clonal Hematopoiesis to Myelodysplastic Neoplasm/Syndromes and Other Myeloid Neoplasms

被引：0

作者：

Xie, Zhuoer ^{[1
]}

Chen, Evan C. C. ^{[2
,3
]}

Mendez, Lourdes M. ^{[4
,5
]}

Komrokji, Rami ^{[1
]}

Zeidan, Amer M. ^{[4
,5
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Malignant Hematol Dept, Tampa, FL USA

[2] Dana Farber Canc Inst, Dept Med Oncol, Adult Leukemia Program, Boston, MA USA

[3] Harvard Med Sch, Boston, MA USA

[4] Yale Univ, Yale Canc Ctr, Dept Internal Med, Sect Hematol,Sch Med, 37 Coll St,First Floor, New Haven, CT 06510 USA

[5] Yale Univ, Smilow Canc Hosp, Sch Med, 37 Coll St,First Floor, New Haven, CT 06510 USA

来源：

CANCER JOURNAL | 2023年 / 29卷 / 03期

关键词：

AML; CCUS; CHIP; CMUS; MDS; SOMATIC MUTATIONS; RISK; COMMON; CHIP; PREVALENCE; DYNAMICS; CELLS; MDS;

D O I：

10.1097/PPO.0000000000000656

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clonal hematopoiesis (CH) confers a high risk of aging-related diseases and hematologic malignancy. There are still significant knowledge gaps in identifying high-risk patients with CH and managing such patients. In this review, we focus on 3 areas: (1) the natural history of CH; (2) the risks of progression of CH, including CH of indeterminate potential, clonal cytopenia of undetermined significance, and therapy-related CH, to myeloid malignancy; and (3) the challenges and unmet needs of CH management and research.

引用

页码：130 / 137

页数：8

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