Spectrum From Clonal Hematopoiesis to Myelodysplastic Neoplasm/Syndromes and Other Myeloid Neoplasms

被引：0

作者：

Xie, Zhuoer ^{[1
]}

Chen, Evan C. C. ^{[2
,3
]}

Mendez, Lourdes M. ^{[4
,5
]}

Komrokji, Rami ^{[1
]}

Zeidan, Amer M. ^{[4
,5
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Malignant Hematol Dept, Tampa, FL USA

[2] Dana Farber Canc Inst, Dept Med Oncol, Adult Leukemia Program, Boston, MA USA

[3] Harvard Med Sch, Boston, MA USA

[4] Yale Univ, Yale Canc Ctr, Dept Internal Med, Sect Hematol,Sch Med, 37 Coll St,First Floor, New Haven, CT 06510 USA

[5] Yale Univ, Smilow Canc Hosp, Sch Med, 37 Coll St,First Floor, New Haven, CT 06510 USA

来源：

CANCER JOURNAL | 2023年 / 29卷 / 03期

关键词：

AML; CCUS; CHIP; CMUS; MDS; SOMATIC MUTATIONS; RISK; COMMON; CHIP; PREVALENCE; DYNAMICS; CELLS; MDS;

D O I：

10.1097/PPO.0000000000000656

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clonal hematopoiesis (CH) confers a high risk of aging-related diseases and hematologic malignancy. There are still significant knowledge gaps in identifying high-risk patients with CH and managing such patients. In this review, we focus on 3 areas: (1) the natural history of CH; (2) the risks of progression of CH, including CH of indeterminate potential, clonal cytopenia of undetermined significance, and therapy-related CH, to myeloid malignancy; and (3) the challenges and unmet needs of CH management and research.

引用

页码：130 / 137

页数：8

共 71 条

[1] Prediction of acute myeloid leukaemia risk in healthy individuals [J].

Abelson, Sagi ;

Collord, Grace ;

Ng, Stanley W. K. ;

Weissbrod, Omer ;

Cohen, Netta Mendelson ;

Niemeyer, Elisabeth ;

Barda, Noam ;

Zuzarte, Philip C. ;

Heisler, Lawrence ;

Sundaravadanam, Yogi ;

Luben, Robert ;

Hayat, Shabina ;

Wang, Ting Ting ;

Zhao, Zhen ;

Cirlan, Julia ;

Pugh, Trevor J. ;

Soave, David ;

Ng, Karen ;

Latimer, Calli ;

Hardy, Claire ;

Raine, Keiran ;

Jones, David ;

Hoult, Diana ;

Britten, Abigail ;

McPherson, John D. ;

Johansson, Mattias ;

Mbabaali, Faridah ;

Eagles, Jenna ;

Millers, Jessica K. ;

Pasternack, Danielle ;

Timms, Lee ;

Krzyzanowski, Paul ;

Awadalla, Philip ;

Costa, Rui ;

Segal, Eran ;

Bratman, Scott, V ;

Beer, Philip ;

Behjati, Sam ;

Martincorena, Inigo ;

Wang, Jean C. Y. ;

Bowles, Kristian M. ;

Ramon Quiros, J. ;

Karakatsani, Anna ;

La Vecchia, Carlo ;

Trichopoulou, Antonia ;

Salamanca-Fernandez, Elena ;

Huerta, Jose M. ;

Barricarte, Aurelio ;

Travis, Ruth C. ;

Tumino, Rosario .

NATURE, 2018, 559 (7714) :400-+

[2] Ultra-sensitive Sequencing Identifies High Prevalence of Clonal Hematopoiesis-Associated Mutations throughout Adult Life [J].

Acuna-Hidalgo, Rocio ;

Sengul, Hilal ;

Steehouwer, Marloes ;

van de Vorst, Maartje ;

Vermeulen, Sita H. ;

Kiemeney, Lambertus A. L. M. ;

Veltman, Joris A. ;

Gilissen, Christian ;

Hoischen, Alexander .

AMERICAN JOURNAL OF HUMAN GENETICS, 2017, 101 (01) :50-64

[3] Clonal hematopoiesis in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis [J].

Arends, Christopher Maximilian ;

Weiss, Marlene ;

Christen, Friederike ;

Eulenberg-Gustavus, Claudia ;

Rousselle, Anthony ;

Kettritz, Ralph ;

Eckardt, Kai-Uwe ;

Chan, Willy ;

Hoyer, Kaja ;

Frick, Mareike ;

Bullinger, Lars ;

Bieringer, Markus ;

Schreiber, Adrian ;

Damm, Frederik .

HAEMATOLOGICA, 2020, 105 (06) :E264-E267

[4] Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis [J].

Arends, Christopher Maximilian ;

Galan-Sousa, Joel ;

Hoyer, Kaja ;

Chan, Willy ;

Jaeger, Marten ;

Yoshida, Kenichi ;

Seemann, Ricarda ;

Noerenberg, Daniel ;

Waldhueter, Nils ;

Fleischer-Notter, Helga ;

Christen, Friederike ;

Schmitt, Clemens A. ;

Doerken, Bernd ;

Pelzer, Uwe ;

Sinn, Marianne ;

Zemojtel, Tomasz ;

Ogawa, Seishi ;

Maerdian, Sven ;

Schreiber, Adrian ;

Kunitz, Annegret ;

Krueger, Ulrike ;

Bullinger, Lars ;

Mylonas, Elena ;

Frick, Mareike ;

Damm, Frederik .

LEUKEMIA, 2018, 32 (09) :1908-1919

[5] Molecular patterns in cytopenia patients with or without evidence of myeloid neoplasm-a comparison of 756 cases [J].

Baer, Constance ;

Pohlkamp, Christian ;

Haferlach, Claudia ;

Kern, Wolfgang ;

Haferlach, Torsten .

LEUKEMIA, 2018, 32 (10) :2295-2298

[6]

Bailey MH, 2018, CELL, V173, P371, DOI [10.1016/j.cell.2018.02.060, 10.1016/j.cell.2018.07.034]

[7] Clonal Hematopoiesis Is Associated With Higher Risk of Stroke [J].

Bhattacharya, Romit ;

Zekavat, Seyedeh M. ;

Haessler, Jeffrey ;

Fornage, Myriam ;

Raffield, Laura ;

Uddin, Md Mesbah ;

Bick, Alexander G. ;

Niroula, Abhishek ;

Yu, Bing ;

Gibson, Christopher ;

Griffin, Gabriel ;

Morrison, Alanna C. ;

Psaty, Bruce M. ;

Longstreth, William T. ;

Bis, Joshua C. ;

Rich, Stephen S. ;

Rotter, Jerome, I ;

Tracy, Russell P. ;

Correa, Adolfo ;

Seshadri, Sudha ;

Johnson, Andrew ;

Collins, Jason M. ;

Hayden, Kathleen M. ;

Madsen, Tracy E. ;

Ballantyne, Christie M. ;

Jaiswal, Siddhartha ;

Ebert, Benjamin L. ;

Kooperberg, Charles ;

Manson, JoAnn E. ;

Whitsel, Eric A. ;

Natarajan, Pradeep ;

Reiner, Alexander P. .

STROKE, 2022, 53 (03) :788-797

[8] Cancer therapy shapes the fitness landscape of clonal hematopoiesis [J].

Bolton, Kelly L. ;

Ptashkin, Ryan N. ;

Gao, Teng ;

Braunstein, Lior ;

Devlin, Sean M. ;

Kelly, Daniel ;

Patel, Minal ;

Berthon, Antonin ;

Syed, Aijazuddin ;

Yabe, Mariko ;

Coombs, Catherine C. ;

Caltabellotta, Nicole M. ;

Walsh, Mike ;

Offit, Kenneth ;

Stadler, Zsofia ;

Mandelker, Diana ;

Schulman, Jessica ;

Patel, Akshar ;

Philip, John ;

Bernard, Elsa ;

Gundem, Gunes ;

Ossa, Juan E. Arango ;

Levine, Max ;

Martinez, Juan S. Medina ;

Farnoud, Noushin ;

Glodzik, Dominik ;

Li, Sonya ;

Robson, Mark E. ;

Lee, Choonsik ;

Pharoah, Paul D. P. ;

Stopsack, Konrad H. ;

Spitzer, Barbara ;

Mantha, Simon ;

Fagin, James ;

Boucai, Laura ;

Gibson, Christopher J. ;

Ebert, Benjamin L. ;

Young, Andrew L. ;

Druley, Todd ;

Takahashi, Koichi ;

Gillis, Nancy ;

Ball, Markus ;

Padron, Eric ;

Hyman, David M. ;

Baselga, Jose ;

Norton, Larry ;

Gardos, Stuart ;

Klimek, Virginia M. ;

Scher, Howard ;

Bajorin, Dean .

NATURE GENETICS, 2020, 52 (11) :1219-+

[9] The Clinical Management of Clonal Hematopoiesis Creation of a Clonal Hematopoiesis Clinic [J].

Bolton, Kelly L. ;

Zehir, Ahmet ;

Ptashkin, Ryan N. ;

Patel, Minal ;

Gupta, Dipti ;

Sidlow, Robert ;

Papaemmanuil, Elli ;

Berger, Michael F. ;

Levine, Ross L. .

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2020, 34 (02) :357-+

[10] Managing Clonal Hematopoiesis in Patients With Solid Tumors [J].

Bolton, Kelly L. ;

Gillis, Nancy K. ;

Coombs, Catherine C. ;

Takahashi, Koichi ;

Zehir, Ahmet ;

Bejar, Rafael ;

Garcia-Manero, Guillermo ;

Futreal, Andrew ;

Jensen, Brian C. ;

Diaz, Luis A., Jr. ;

Gupta, Dipti ;

Mantha, Simon ;

Klimek, Virginia ;

Papaemmanuil, Elli ;

Levine, Ross ;

Padron, Eric .

JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (01) :7-+

← 1 2 3 4 5 6 7 8 →