Human FOXP3 and tumour microenvironment

被引：63

作者：

Wang, Jia ^{[1
,2
]}

Gong, Ruining ^{[1
]}

Zhao, Chenyang ^{[1
]}

Lei, Ke ^{[1
]}

Sun, Xiaoyuan ^{[3
]}

Ren, He ^{[1
,4
]}

机构：

[1] Qingdao Univ, Ctr Tumor Immunol & Cytotherapy, Med Res Ctr, Affiliated Hosp, 1677 Wutaishan Rd, Qingdao 266003, Shandong, Peoples R China

[2] Qingdao Univ, Qingdao Med Sch, Qingdao, Shandong, Peoples R China

[3] Harbin Med Univ, Dept Gastrointestinal Med Oncol, Canc Hosp, Harbin, Heilongjiang, Peoples R China

[4] Tianjin Med Univ Canc Inst & Hosp, Dept Pancreat Canc, Tianjin, Peoples R China

来源：

IMMUNOLOGY | 2023年 / 168卷 / 02期

基金：

中国博士后科学基金;

关键词：

FOXP3; Treg-FOXP3; tumour microenvironment; tumour-FOXP3; REGULATORY T-CELLS; TRANSCRIPTION FACTOR; TREG CELLS; CANCER; EXPRESSION; INTERLEUKIN-35; MAINTENANCE; DIFFERENTIATION; AUTOIMMUNITY; SUPPRESSION;

D O I：

10.1111/imm.13520

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The tumour microenvironment (TME) is a complex system composed of cancer cells, stromal cells and immune cells. Regulatory T cells (Tregs) in the TME impede immune surveillance of tumours and suppress antitumor immune responses. Transcription factor forkhead box protein 3 (FOXP3) is the main marker of Tregs, which dominates the function of Tregs. FOXP3 was originally thought to be a Tregs-specific expression molecule, and recent studies have found that FOXP3 is expressed in a variety of tumours with inconsistent functional roles. This review summarizes the recent progress of infiltrating Treg-FOXP3 and tumour-FOXP3 in TME, discusses the communication mechanism between FOXP3(+) cells and effector T cells in TME, the relationship between FOXP3 and clinical prognosis, and the potential of FOXP3-targeted therapy.

引用

页码：248 / 255

页数：8

共 50 条

[31] Functional Analysis of FOXP3
Buckner, Jane H.
Ziegler, Steven F.
YEAR IN IMMUNOLOGY 2008, 2008, 1143 : 151 - 169
[32] Foxp3 and dominant tolerance
Rudensky, A
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2005, 360 (1461) : 1645 - 1646
[33] What turns on Foxp3?
Harald von Boehmer
Jens Nolting
Nature Immunology, 2008, 9 : 121 - 122
[34] FoxP3 partners up
David Bending
Masahiro Ono
Nature Immunology, 2017, 18 : 1181 - 1183
[35] FOXP3: Of mice and men
Ziegler, Steven F.
ANNUAL REVIEW OF IMMUNOLOGY, 2006, 24 : 209 - 226
[36] Foxp3: Shades of Tolerance
Chatila, Talal A.
Williams, Calvin B.
IMMUNITY, 2012, 36 (05) : 693 - 694
[37] What turns on Foxp3?
von Boehmer, Harald
Nolting, Jens
NATURE IMMUNOLOGY, 2008, 9 (02) : 121 - 122
[38] Visualizing the Fate of Foxp3 Protein in Human T Cells
Magg, Thomas
Albert, Michael
CLINICAL IMMUNOLOGY, 2009, 131 : S166 - S167
[39] Leading role for FOXP3
Bell, J
NATURE REVIEWS IMMUNOLOGY, 2003, 3 (02) : 95 - 95
[40] Both tumour cells and infiltrating T-cells in equine sarcoids express FOXP3 associated with an immune-supressed cytokine microenvironment
A. Douglas Wilson
Chelsea Hicks
Veterinary Research, 47

← 1 2 3 4 5 →