Human FOXP3 and tumour microenvironment

被引：63
|
作者：
Wang, Jia [1 ,2 ]
Gong, Ruining [1 ]
Zhao, Chenyang [1 ]
Lei, Ke [1 ]
Sun, Xiaoyuan [3 ]
Ren, He [1 ,4 ]
机构：
[1] Qingdao Univ, Ctr Tumor Immunol & Cytotherapy, Med Res Ctr, Affiliated Hosp, 1677 Wutaishan Rd, Qingdao 266003, Shandong, Peoples R China
[2] Qingdao Univ, Qingdao Med Sch, Qingdao, Shandong, Peoples R China
[3] Harbin Med Univ, Dept Gastrointestinal Med Oncol, Canc Hosp, Harbin, Heilongjiang, Peoples R China
[4] Tianjin Med Univ Canc Inst & Hosp, Dept Pancreat Canc, Tianjin, Peoples R China
来源：
IMMUNOLOGY | 2023年 / 168卷 / 02期
基金：
中国博士后科学基金;
关键词：
FOXP3; Treg-FOXP3; tumour microenvironment; tumour-FOXP3; REGULATORY T-CELLS; TRANSCRIPTION FACTOR; TREG CELLS; CANCER; EXPRESSION; INTERLEUKIN-35; MAINTENANCE; DIFFERENTIATION; AUTOIMMUNITY; SUPPRESSION;
D O I：
10.1111/imm.13520
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The tumour microenvironment (TME) is a complex system composed of cancer cells, stromal cells and immune cells. Regulatory T cells (Tregs) in the TME impede immune surveillance of tumours and suppress antitumor immune responses. Transcription factor forkhead box protein 3 (FOXP3) is the main marker of Tregs, which dominates the function of Tregs. FOXP3 was originally thought to be a Tregs-specific expression molecule, and recent studies have found that FOXP3 is expressed in a variety of tumours with inconsistent functional roles. This review summarizes the recent progress of infiltrating Treg-FOXP3 and tumour-FOXP3 in TME, discusses the communication mechanism between FOXP3(+) cells and effector T cells in TME, the relationship between FOXP3 and clinical prognosis, and the potential of FOXP3-targeted therapy.
引用
收藏
页码：248 / 255
页数：8
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