The role of microRNAs involved in the disorder of blood-brain barrier in the pathogenesis of multiple sclerosis

被引：9

作者：

Nejad, Asieh Emami ^{[1
]}

Zadeh, Seyed Mostafa Mostafavi ^{[2
,3
]}

Nickho, Hamid ^{[4
]}

Abbasian, Ali Sadoogh ^{[5
]}

Forouzan, Azim ^{[5
]}

Ahmadlou, Mojtaba ^{[6
]}

Nedaeinia, Reza ^{[7
]}

Shaverdi, Saham ^{[1
]}

Manian, Mostafa ^{[8
,9
]}

机构：

[1] Payame Noor Univ PNU, Dept Biol, Tehran, Iran

[2] Iran Univ Med Sci, Fac Adv Technol Med, Dept Mol Med, Tehran, Iran

[3] Iran Univ Med Sci, Oncopathol Res Ctr, Tehran, Iran

[4] Iran Univ Med Sci, Fac Med, Dept Immunol, Tehran, Iran

[5] Arak Univ Med Sci, Amiralmomenin Hosp, Sch Med, Dept Internal Med, Arak, Iran

[6] Arak Univ Med Sci, Sch Med, Dept Biostat, Arak, Iran

[7] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Pediat Inherited Dis Res Ctr, Esfahan, Iran

[8] Islamic Azad Univ, Fac Med, Dept Med Lab Sci, Kermanshah, Iran

[9] Isfahan Univ Med Sci, Neurosci Res Ctr, Esfahan, Iran

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

miRNAs; autoimmune; multiple sclerosis; exosomes; therapeutic advances; CENTRAL-NERVOUS-SYSTEM; CIRCULATING MICRORNAS; TH17; DIFFERENTIATION; PERIPHERAL-BLOOD; NONCODING RNAS; EMERGING ROLE; EXPRESSION; BIOMARKERS; DISEASE; MIRNAS;

D O I：

10.3389/fimmu.2023.1281567

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

miRNAs are involved in various vital processes, including cell growth, development, apoptosis, cellular differentiation, and pathological cellular activities. Circulating miRNAs can be detected in various body fluids including serum, plasma, saliva, and urine. It is worth mentioning that miRNAs remain stable in the circulation in biological fluids and are released from membrane-bound vesicles called exosomes, which protect them from RNase activity. It has been shown that miRNAs regulate blood-brain barrier integrity by targeting both tight junction and adherens junction molecules and can also influence the expression of inflammatory cytokines. Some recent studies have examined the impact of certain commonly used drugs in Multiple Sclerosis on miRNA levels. In this review, we will focus on the recent findings on the role of miRNAs in multiple sclerosis, including their role in the cause of MS and molecular mechanisms of the disease, utilizing miRNAs as diagnostic and clinical biomarkers, using miRNAs as a therapeutic modality or target for Multiple Sclerosis and drug responses in patients, elucidating their importance as prognosticators of disease progression, and highlighting their potential as a future treatment for MS.

引用

页数：16

共 139 条

[1] miR-27a and miR-214 exert opposite regulatory roles in Th17 differentiation via mediating different signaling pathways in peripheral blood CD4+ T lymphocytes of patients with relapsing-remitting multiple sclerosis [J].