The impact of diabetes mellitus on the emergence of multi-drug resistant tuberculosis and treatment failure in TB-diabetes comorbid patients: a systematic review and meta-analysis

被引：20

作者：

Rehman, Anees ur ^{[1
]}

Khattak, Mahnoor ^{[1
]}

Mushtaq, Usman ^{[2
]}

Latif, Muhammad ^{[3
]}

Ahmad, Imran ^{[4
]}

Rasool, Muhammad Fawad ^{[1
]}

Shakeel, Sadia ^{[5
]}

Hayat, Khezar ^{[6
]}

Hussain, Rabia ^{[7
]}

Alhazmi, Ghaidaa Ali ^{[8
]}

Alshomrani, Afnan Owedah ^{[9
]}

Alalawi, Mohammed Ibrahim ^{[10
]}

Alghamdi, Saleh ^{[11
]}

Imam, Mohammad Tarique ^{[12
]}

Almarzoky Abuhussain, Safa S. ^{[13
]}

Khayyat, Sarah M. ^{[13
]}

Haseeb, Abdul ^{[13
]}

机构：

[1] Bahauddin Zakariya Univ, Fac Pharm, Dept Pharm Practice, Multan, Pakistan

[2] Nishter Med Univ & Hosp, Multan, Pakistan

[3] Univ Educ Lahore, Dept Zool, Div Sci & Technol, Lahore, Pakistan

[4] Bahauddin Zakariya Univ, Fac Pharm, Dept Pharmaceut Chem, Multan, Pakistan

[5] Dow Univ Hlth Sci, Fac Pharmaceut Sci, Dept Pharm Practice, Karachi, Pakistan

[6] Univ Vet & Anim Sci, Inst Pharmaceut Sci, Lahore, Pakistan

[7] Univ Sains Malaysia, Sch Pharmaceut Sci, George Town, Malaysia

[8] Minist Hlth, Dept Pharm, King Abdullah Med City, Mecca, Saudi Arabia

[9] Minist Natl Guard Hlth Affairs, Pharmaceut Care Dept, King Abdulaziz Med City, Jeddah, Saudi Arabia

[10] Alnoor Specialist Hosp, Dept Internal Med, Mecca, Saudi Arabia

[11] Al Baha Univ, Fac Clin Pharm, Dept Clin Pharm, Al Baha, Saudi Arabia

[12] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Clin Pharm, Al Kharj, Saudi Arabia

[13] Umm Al Qura Univ, Coll Pharm, Clin Pharm Dept, Mecca, Saudi Arabia

来源：

FRONTIERS IN PUBLIC HEALTH | 2023年 / 11卷

关键词：

tuberculosis; diabetes mellitus; TB-DM comorbidity; multi-drug resistant TB; treatment failure; disease progression; PULMONARY TUBERCULOSIS; RISK-FACTORS; TREATMENT RESPONSE; DRUG-RESISTANCE; PREVALENCE; POPULATION;

D O I：

10.3389/fpubh.2023.1244450

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: The existence of Type 2 Diabetes Mellitus (DM) in tuberculosis (TB) patients is very dangerous for the health of patients. One of the major concerns is the emergence of MDR-TB in such patients. It is suspected that the development of MDR-TB further worsens the treatment outcomes of TB such as treatment failure and thus, causes disease progression.Aim: To investigate the impact of DM on the Emergence of MDR-TB and Treatment Failure in TB-DM comorbid patients.Methodology: The PubMed database was systematically searched until April 03, 2022 (date last searched). Thirty studies met the inclusion criteria and were included in this study after a proper selection process.Results: Tuberculosis-Diabetes Mellitus patients were at higher risk to develop MDR-TB as compared to TB-non-DM patients (HR 0.81, 95% CI: 0.60-0.96, p < 0.001). Heterogeneity observed among included studies was moderate (I2 = 38%). No significant change was observed in the results after sub-group analysis by study design (HR 0.81, 95% CI: 0.61-0.96, p < 0.000). In the case of treatment failure, TB-DM patients were at higher risk to experience treatment failure rates as compared to TB-non-DM patients (HR 0.46, 95% CI: 0.27-0.67, p < 0.001).Conclusion: The results showed that DM had a significant impact on the emergence of MDR-TB in TB-diabetes comorbid patients as compared to TB-non-DM patients. DM enhanced the risk of TB treatment failure rates in TB-diabetes patients as compared to TB-non-DM patients. Our study highlights the need for earlier screening of MDR-TB, thorough MDR-TB monitoring, and designing proper and effective treatment strategies to prevent disease progression.

引用

页数：11