The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis

被引：42

作者：

Shirani, Maryam ^{[1
]}

Pakzad, Reza ^{[2
,3
]}

Haddadi, Mohammad Hossein ^{[4
]}

Akrami, Sousan ^{[5
,6
]}

Asadi, Arezoo ^{[7
]}

Kazemian, Hossein ^{[4
]}

Moradi, Melika ^{[6
]}

Kaviar, Vahab Hassan ^{[8
]}

Zomorodi, Abolfazl Rafati ^{[9
]}

Khoshnood, Saeed ^{[3
,4
]}

Shafieian, Mahnaz ^{[10
]}

Tavasolian, Ronia ^{[11
]}

Heidary, Mohsen ^{[12
,13
]}

Saki, Morteza ^{[6
]}

机构：

[1] Ahvaz Jundishapur Univ Med Sci, Med Basic Sci Res Inst, Toxicol Res Ctr, Ahvaz, Iran

[2] Ilam Univ Med Sci, Fac Hlth, Dept Epidemiol, Ilam, Iran

[3] Ilam Univ Med Sci, Student Res Comm, Ilam, Iran

[4] Ilam Univ Med Sci, Clin Microbiol Res Ctr, Ilam, Iran

[5] Univ Tehran Med Sci, Students Sci Res Ctr SSRC, Tehran, Iran

[6] Ahvaz Jundishapur Univ Med Sci, Fac Med, Dept Microbiol, Ahvaz, Iran

[7] Iran Univ Med Sci, Inst Endocrinol & Metab, Endocrine Res Ctr, Tehran, Iran

[8] Ilam Univ Med Sci, Fac Med, Dept Med Microbiol, Ilam, Iran

[9] Shiraz Univ Med Sci, Sch Med, Dept Bacteriol & Virol, Shiraz, Iran

[10] Ilam Univ Med Sci, Fac Nursing & Midwifery, Dept Midwifery, Ilam, Iran

[11] Univ Cheste, Fac Nutr Sci, Dept Med, Chester, England

[12] Sabzevar Univ Med Sci, Sch Paramed Sci, Dept Lab Sci, Sabzevar, Iran

[13] Sabzevar Univ Med Sci, Cellular & Mol Res Ctr, Sabzevar, Iran

来源：

BMC INFECTIOUS DISEASES | 2023年 / 23卷 / 01期

关键词：

Infection; Prevalence; Gastric cancer; Helicobacter pylori; Systematic review; Meta-analysis; PEPTIC-ULCER DISEASE; DYSPEPTIC PATIENTS; FOLLOW-UP; HIGH-RISK; ANTIBIOTIC-RESISTANCE; VIRULENCE FACTORS; SERUM PEPSINOGEN; IRANIAN PATIENTS; POTENTIAL ROLE; TNF-ALPHA;

D O I：

10.1186/s12879-023-08504-5

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

BackgroundHelicobacter pylori is a gastrointestinal pathogen that infects around half of the world's population. H. pylori infection is the most severe known risk factor for gastric cancer (GC), which is the second highest cause of cancer-related deaths globally. We conducted a systematic review and meta-analysis to assess the global prevalence of GC in H. pylori-infected individuals.MethodsWe performed a systematic search of the PubMed, Web of Science, and Embase databases for studies of the prevalence of GC in H. pylori-infected individuals published from 1 January 2011 to 20 April 2021. Metaprop package were used to calculate the pooled prevalence with 95% confidence interval. Random-effects model was applied to estimate the pooled prevalence. We also quantified it with the I-2 index. Based on the Higgins classification approach, I-2 values above 0.7 were determined as high heterogeneity.ResultsAmong 17,438 reports screened, we assessed 1053 full-text articles for eligibility; 149 were included in the final analysis, comprising data from 32 countries. The highest and lowest prevalence was observed in America (pooled prevalence: 18.06%; 95% CI: 16.48 - 19.63; I-2: 98.84%) and Africa (pooled prevalence: 9.52%; 95% CI: 5.92 - 13.12; I-2: 88.39%). Among individual countries, Japan had the highest pooled prevalence of GC in H. pylori positive patients (Prevalence: 90.90%:95% CI: 83.61-95.14), whereas Sweden had the lowest prevalence (Prevalence: 0.07%; 95% CI: 0.06-0.09). The highest and lowest prevalence was observed in prospective case series (pooled prevalence: 23.13%; 95% CI: 20.41 - 25.85; I2: 97.70%) and retrospective cohort (pooled prevalence: 1.17%; 95% CI: 0.55 - 1.78; I 2: 0.10%).ConclusionsH. pylori infection in GC patients varied between regions in this systematic review and meta-analysis. We observed that large amounts of GCs in developed countries are associated with H. pylori. Using these data, regional initiatives can be taken to prevent and eradicate H. pylori worldwide, thus reducing its complications.

引用

页数：30

共 189 条

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