The Prognostic Value of Olfactory Dysfunction in Patients with COVID-19: The COVIDORA Study

被引：0

作者：

Hamel, Anne-Laure ^{[1
]}

Delbos, Leo ^{[2
,3
]}

Natella, Pierre-Andre ^{[1
]}

Radulesco, Thomas ^{[4
,5
]}

Alexandru, Mihaela ^{[3
,6
,7
]}

Bartaire, Emmanuel ^{[8
,9
,10
]}

Bartier, Sophie ^{[11
,12
,13
]}

Benoite, Gonda ^{[14
]}

Bequignon, Emilie ^{[12
,13
,15
]}

Castillo, Laurent ^{[16
]}

Canoui-Poitrine, Florence ^{[12
,13
,17
]}

Carsuzaa, Florent ^{[18
,19
]}

Corre, Alain ^{[20
]}

Coste, Andre ^{[12
,13
,15
]}

Couloigner, Vincent ^{[21
,22
]}

Daveau, Clementine ^{[23
]}

De Boissieu, Paul ^{[2
]}

De Bonnecaze, Guillaume ^{[24
,25
,26
]}

De Gabory, Ludovic ^{[27
]}

Debry, Christian ^{[28
,29
]}

Deraedt, Simon ^{[30
]}

Dufour, Xavier ^{[18
]}

El Bakkouri, Wissame ^{[20
]}

Gilain, Laurent ^{[31
,32
]}

Hans, Stephane ^{[33
]}

Hautefort, Charlotte ^{[34
,35
]}

Hermann, Ruben ^{[36
,37
,38
]}

Jankowski, Roger ^{[39
,40
]}

La Croix, Candice ^{[41
]}

Lecanu, Jean-Baptiste ^{[42
]}

Malard, Olivier ^{[43
,44
]}

Michel, Justin ^{[4
,5
]}

Nguyen, Yann ^{[45
,46
]}

Nevoux, Jerome ^{[3
,6
,7
]}

Papon, Jean-Francois ^{[3
,6
,7
]}

Patron, Vincent ^{[47
]}

Prigent, Marine ^{[48
]}

Pruliere-Escabasse, Virginie ^{[12
,15
]}

Renaud, Marion ^{[28
]}

Rumeau, Cecile ^{[39
,40
]}

Salmon, Dominique ^{[49
]}

Saroul, Nicolas ^{[31
,32
]}

Serrano, Elie ^{[24
,25
]}

Nhung Tran Khai, Christine ^{[3
,6
]}

Tringali, Stephane ^{[38
,50
,51
]}

Truy, Eric ^{[36
,38
]}

Vandersteen, Clair ^{[16
,52
]}

Verillaud, Benjamin ^{[34
,35
]}

Veil, Raphael ^{[2
,3
]}

Fieux, Maxime ^{[38
,50
,51
]}

机构：

[1] Hop Henri Mondor, AP HP, URC, F-94010 Creteil, France

[2] Hop Bicetre, AP HP, Serv St Publ & Epidemiol, F-94270 Paris, France

[3] Univ Paris Saclay, F-91190 Gif Sur Yvettes, France

[4] La Conception Univ Hosp, Dept Oto Rhino Laryngol Head & Neck Surg, F-13005 Marseille, France

[5] Aix Marseille Univ, APHM, CNRS, IUSTI, F-13005 Marseille, France

[6] Hop Bicetre, AP HP, Serv ORL, F-94270 Paris, France

[7] Sorbonne Univ, INSERM, UMR S933, Genet Dis Pediat Express, F-75005 Paris, France

[8] Hop St Vincent Depaul, GHICL, F-59000 Lille, France

[9] Ctr St SOMeD, F-59777 Lille, France

[10] Ctr St Richerand, F-75010 Paris, France

[11] Hop Henri Mondor, AP HP, Serv ORL & Chirurg Cerv Faciale, F-94010 Creteil, France

[12] Univ Paris Est Creteil, INSERM, IMRB, F-94010 Creteil, France

[13] CNRS, EMR 7000, F-94010 Creteil, France

[14] Hop St Vincent Depaul, Fac Libre Med Lille, Delegat Rech Clin & Innovat, GHICL, F-59000 Lille, France

[15] Ctr Hosp Inter Communal Creteil, Serv ORL & Chirurg Cerv Faciale, F-94010 Creteil, France

[16] Univ Cote Azur, Inst Univ Face & Cou, CHU, F-06100 Nice, France

[17] Hop Henri Mondor, AP HP, Serv St Publ, F-94010 Creteil, France

[18] Ctr Hosp Univ Poitiers, Serv ORL Chirurg Cerv Faciale & Audiophonol, F-86000 Poitiers, France

[19] Univ Poitiers, LITEC, UR15560, F-86000 Poitiers, France

[20] Hop Fdn Rothschild, Serv ORL & Chirurg Cerv Faciale, F-75019 Paris, France

[21] Hop Necker Enfants Malad, AP HP, Serv ORL Pediat, F-75015 Paris, France

[22] Univ Paris Cite, F-75015 Paris, France

[23] Hosp Civils Lyon, Hop Croix Rousse, Serv ORL & Chirurg Cerv Faciale, F-69004 Lyon, France

[24] Hop Larrey, Serv ORL & Chirurg Cerv Faciale, Pole Clin Voies Resp, F-31059 Toulouse, France

[25] Univ Paul Sabatier Toulouse III, F-31062 Toulouse, France

[26] Univ Paul Sabatier Toulouse III, Lab Ctr Anthropobiol & Genom Toulouse, F-31059 Toulouse, France

[27] Ctr Hosp Univ Bordeaux, Serv ORL & Chirurg Cerv Faciale, F-33000 Bordeaux, France

[28] Hop Hautepierre, Hop Univ Strasbourg, Serv ORL & Chirurg Cerv Faciale, F-67200 Strasbourg, France

[29] CRBS, Unite INSERM Biomat & Bioingn 1121, F-67000 Strasbourg, France

[30] Hop St Vincent Depaul, Fac Libre Med Lille, Serv ORL & Chirurg Cerv Faciale, GHICL, F-59000 Lille, France

[31] Hop Univ Gabriel Montpied, Serv ORL & Chirurg Cerv Faciale, F-63000 Clermont Ferrand, France

[32] Univ Clermont Auvergne, Un Nutr Humaine, Equipe ASMS UMR 1019, INRAE, F-63000 Clermont Ferrand, France

[33] Univ Paris Saclay, Hop Foch, Serv ORL & Chirurg Cerv Faciale, F-92150 Paris, France

[34] Hop Lariboisiere, AP HP, Serv ORL & Chirurg Cerv Faciale, F-75010 Paris, France

[35] Univ Paris, Hop Robert Debre, INSERM, U1141 NeuroDiderot, F-75019 Paris, France

[36] Hosp Civils Lyon, Hop Edouard Herriot, Serv ORL Chirurg Cerv Faciale & Audiophonol, F-69003 Lyon, France

[37] INSERM, CNRS, Lyon Neurosci Res Ctr, ImpAct Team,U1028,UMR5292, F-69500 Bron, France

[38] Univ Lyon 1, Univ Lyon, F-69003 Lyon, France

[39] Univ Lorraine, Serv ORL, CHRU Nancy, F-54000 Nancy, France

[40] Univ Lorraine, DevAH, F-54000 Nancy, France

[41] Hop Cochin, AP HP, Serv ORL & Chirurg Cerv Faciale, F-75014 Paris, France

[42] Inst Arthur Vernes, Serv ORL & Chirurg Cerv Faciale, F-75006 Paris, France

[43] Ctr Hosp Univ Nante, Hop Univ Nantes, Serv ORL & Chirurg Cerv Faciale, 1 Pl A Ricordeau Hotel Dieu, F-44093 Nantes, France

[44] INSERM, UMRS 1229, Regenerat Med & Skeleton RMeS, F-44093 Nantes, France

[45] GHU Pitie Salpetriere, AP HP, Serv ORL, F-75013 Paris, France

[46] Sorbonne Univ, Fac Med, F-75012 Paris, France

[47] Hop Univ Caen, Serv ORL & Chirurg Cerv Faciale, F-14000 Caen, France

[48] Hop Robert Debre, AP HP, Serv ORL & Chirurg Cerv Faciale, F-75019 Paris, France

[49] Univ Paris Cite, AP HP, Direct Relat Int, F-75270 Paris, France

[50] Hosp Civils Lyon, Ctr Hosp Lyon Sud, Serv ORL Otoneurochirurg & Chirurg Cerv Faciale, F-69310 Pierre Benite, France

来源：

LIFE-BASEL | 2024年 / 14卷 / 03期

关键词：

olfactory dysfunction; anosmia; phantosmia; parosmia; COVID-19; taste dysfunction; risk factors; diabetes; hypertension; renal insufficiency; tobacco; EXPRESSION; SMELL;

D O I：

10.3390/life14030293

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Among all studies describing COVID-19 clinical features during the first wave of the pandemic, only a few retrospective studies have assessed the correlation between olfac-tory dysfunction (OD) and the evolution of disease severity. The main aim was to assess whether OD is a predictive factor of COVID-19 severity based on the patient's medical management (outpa-tient care, standard hospital admission, and ICU admission). Methods: A national, prospective, mul-ticenter cohort study was conducted in 20 public hospitals and a public center for COVID-19 screen-ing. During the first wave of the pandemic, from 6 April to 11 May 2020, all patients tested positive for COVID-19 confirmed by RT-PCR underwent two follow-up ENT consultations within 10 days of symptom onset. The main outcome measures were the evolution of medical management (out-patient care, standard hospital admission, and ICU admission) at diagnosis and along the clinical course of COVID-19 disease. Results: Among 481 patients included, the prevalence of OD was 60.7%, and it affected mostly female patients (74.3%) under 65 years old (92.5%), with fewer comor-bidities than patients with normal olfactory function. Here, 99.3% (290/292) of patients with OD presented with non-severe COVID-19 disease. Patients reporting OD were significantly less hospi-talized than the ones managed as outpatients, in either a standard medical unit or an ICU. Conclu-sions: As regards the clinical course of COVID-19 disease, OD could predict a decreased risk of hospitalization during the first wave of the pandemic.

引用

页数：16

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