Rhodium-Catalyzed Enantioselective Addition of Heteroarenium Salts Enabled by Nucleophilic Cyclization of 2-Alkynylanilines

被引：2

作者：

Huang, Yaling ^{[1
]}

Qi, Zisong ^{[1
]}

Li, Xingwei ^{[1
]}

机构：

[1] Shaanxi Normal Univ SNNU, Sch Chem & Chem Engn, Xian 710062, Shaanxi, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 47期

关键词：

DEAROMATIZATION; INDOLES; ARYLATION; PYRIDINES; HETEROCYCLES;

D O I：

10.1021/acs.orglett.3c03300

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Transition-metal-catalyzed cyclative coupling of 2-alkynylanilines provides a feasible routine for accessing functionalized indoles. Herein, a rhodium-catalyzed highly enantioselective addition of heteroarenium salts is presented, which is enabled by the nucleophilic cyclization of 2-alkynylanilines. It offers feasible protocols to access enantioenriched functionalized indoles tethered to 1,2-dihydropyridine and 1,2-dihydroquinoline motifs with excellent enantioselectivities.

引用

页码：8439 / 8444

页数：6

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