COVID-19: Challenges of Viral Variants

被引：51
作者：
Jacobs, Jana L. [1 ]
Haidar, Ghady [1 ]
Mellors, John W. [1 ]
机构：
[1] Univ Pittsburgh, Sch Med, Dept Med, Div Infect Dis, Pittsburgh, PA 15213 USA
来源：
ANNUAL REVIEW OF MEDICINE | 2023年 / 74卷
关键词：
COVID-19; SARS-CoV-2; variant of concern; VOC; RECEPTOR-BINDING DOMAIN; SARS-COV-2; VARIANTS; OMICRON VARIANT; IMMUNOCOMPROMISED PATIENTS; CLINICAL SEVERITY; UNITED-STATES; TRANSMISSION; MUTATIONS; ADULTS; REPLICATION;
D O I：
10.1146/annurev-med-042921-020956
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The COVID-19 pandemic has been accompanied by SARS-CoV-2 evolution and emergence of viral variants that have far exceeded initial expectations. Five major variants of concern (Alpha, Beta, Gamma, Delta, and Omicron) have emerged, each having both unique and overlapping amino acid substitutions that have affected transmissibility, disease severity, and susceptibility to natural or vaccine-induced immune responses and monoclonal antibodies. Several of the more recent variants appear to have evolved properties of immune evasion, particularly in cases of prolonged infection. Tracking of existing variants and surveillance for new variants are critical for an effective pandemic response.
引用
收藏
页码：31 / 53
页数：23
相关论文
共 125 条
  • [1] Effect of mRNA Vaccine Boosters against SARS-CoV-2 Omicron Infection in Qatar
    Abu-Raddad, L. J.
    Chemaitelly, H.
    Ayoub, H. H.
    AlMukdad, S.
    Yassine, H. M.
    Al-Khatib, H. A.
    Smatti, M. K.
    Tang, P.
    Hasan, M. R.
    Coyle, P.
    Al-Kanaani, Z.
    Al-Kuwari, E.
    Jeremijenko, A.
    Kaleeckal, A. H.
    Latif, A. N.
    Shaik, R. M.
    Abdul-Rahim, H. F.
    Nasrallah, G. K.
    Al-Kuwari, M. G.
    Butt, A. A.
    Al-Romaihi, H. E.
    Al-Thani, M. H.
    Al-Khal, A.
    Bertollini, R.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (19) : 1804 - 1816
  • [2] Severity, Criticality, and Fatality of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Beta Variant
    Abu-Raddad, Laith J.
    Chemaitelly, Hiam
    Ayoub, Houssein H.
    Yassine, Hadi M.
    Benslimane, Fatiha M.
    Al Khatib, Hebah A.
    Tang, Patrick
    Hasan, Mohammad R.
    Coyle, Peter
    AlMukdad, Sawsan
    Al Kanaani, Zaina
    Al Kuwari, Einas
    Jeremijenko, Andrew
    Kaleeckal, Anvar Hassan
    Latif, Ali Nizar
    Shaik, Riyazuddin Mohammad
    Abdul Rahim, Hanan F.
    Nasrallah, Gheyath K.
    Al Kuwari, Mohamed Ghaith
    Butt, Adeel A.
    Al Romaihi, Hamad Eid
    Al-Thani, Mohamed H.
    Al Khal, Abdullatif
    Bertollini, Roberto
    [J]. CLINICAL INFECTIOUS DISEASES, 2022, 75 (01) : E1188 - E1191
  • [3] Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants
    Abu-Raddad, Laith J.
    Chemaitelly, Hiam
    Butt, Adeel A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (02) : 187 - 189
  • [4] Association Between 3 Doses of mRNA COVID-19 Vaccine and Symptomatic Infection Caused by the SARS-CoV-2 Omicron and Delta Variants
    Accorsi, Emma K.
    Britton, Amadea
    Fleming-Dutra, Katherine E.
    Smith, Zachary R.
    Shang, Nong
    Derado, Gordana
    Miller, Joseph
    Schrag, Stephanie J.
    Verani, Jennifer R.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2022, 327 (07): : 639 - 651
  • [5] Household transmission of COVID-19 cases associated with SARS-CoV-2 delta variant (B.1.617.2): national case-control study
    Allen, Hester
    Vusirikala, Amoolya
    Flannagan, Joe
    Twohig, Katherine A.
    Zaidi, Asad
    Chudasama, Dimple
    Lamagni, Theresa
    Groves, Natalie
    Turner, Charlie
    Rawlinson, Christopher
    Lopez-Bernal, Jamie
    Harris, Ross
    Charlett, Andre
    Dabrera, Gavin
    Kall, Meaghan
    [J]. LANCET REGIONAL HEALTH-EUROPE, 2022, 12
  • [6] Andrews N, 2022, NEW ENGL J MED, V386, P1532, DOI [10.1016/S1473-3099(22)00309-7, 10.1056/NEJMoa2119451]
  • [7] [Anonymous], 2022, REUTERS 0405
  • [8] Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer
    Avanzato, Victoria A.
    Matson, M. Jeremiah
    Seifert, Stephanie N.
    Pryce, Rhys
    Williamson, Brandi N.
    Anzick, Sarah L.
    Barbian, Kent
    Judson, Seth D.
    Fischer, Elizabeth R.
    Martens, Craig
    Bowden, Thomas A.
    de Wit, Emmie
    Riedo, Francis X.
    Munster, Vincent J.
    [J]. CELL, 2020, 183 (07) : 1901 - +
  • [9] Shedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for Cancer
    Aydillo, Teresa
    Babady, N. Esther
    Kamboj, Mini
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (26) : 2586 - 2588
  • [10] Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient
    Baang, Ji Hoon
    Smith, Christopher
    Mirabelli, Carmen
    Valesano, Andrew L.
    Manthei, David M.
    Bachman, Michael A.
    Wobus, Christiane E.
    Adams, Michael
    Washer, Laraine
    Martin, Emily T.
    Lauring, Adam S.
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2021, 223 (01) : 23 - 27
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