COVID-19: Challenges of Viral Variants

被引：62

作者：

Jacobs, Jana L. ^{[1
]}

Haidar, Ghady ^{[1
]}

Mellors, John W. ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Med, Div Infect Dis, Pittsburgh, PA 15213 USA

来源：

ANNUAL REVIEW OF MEDICINE | 2023年 / 74卷

关键词：

COVID-19; SARS-CoV-2; variant of concern; VOC; RECEPTOR-BINDING DOMAIN; SARS-COV-2; VARIANTS; OMICRON VARIANT; IMMUNOCOMPROMISED PATIENTS; CLINICAL SEVERITY; UNITED-STATES; TRANSMISSION; MUTATIONS; ADULTS; REPLICATION;

D O I：

10.1146/annurev-med-042921-020956

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The COVID-19 pandemic has been accompanied by SARS-CoV-2 evolution and emergence of viral variants that have far exceeded initial expectations. Five major variants of concern (Alpha, Beta, Gamma, Delta, and Omicron) have emerged, each having both unique and overlapping amino acid substitutions that have affected transmissibility, disease severity, and susceptibility to natural or vaccine-induced immune responses and monoclonal antibodies. Several of the more recent variants appear to have evolved properties of immune evasion, particularly in cases of prolonged infection. Tracking of existing variants and surveillance for new variants are critical for an effective pandemic response.

引用

页码：31 / 53

页数：23

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