Characteristic cerebrospinal fluid findings in immune checkpoint inhibitor-related peripheral neuropathy: A case report

被引：3

作者：

Wako, Sho ^{[1
]}

Ikeguchi, Ryotaro ^{[1
,5
]}

Toda, Kunio ^{[1
]}

Kobayashi, Masaki ^{[1
]}

Miyata, Ryujin ^{[2
]}

Kuramochi, Hidekazu ^{[3
]}

Ichihara, Atsuhiro ^{[4
]}

Shimizu, Yuko ^{[1
]}

Kitagawa, Kazuo ^{[1
]}

机构：

[1] Tokyo Womens Med Univ, Dept Neurol, Tokyo, Japan

[2] Tokyo Womens Med Univ, Dept Dermatol, Tokyo, Japan

[3] Tokyo Womens Med Univ, Dept Chemotherapy & Palliat Care, Tokyo, Japan

[4] Tokyo Womens Med Univ, Dept Endocrinol & Hypertens, Tokyo, Japan

[5] 8-1 Kawada Cho,Shinjuku Ku, Tokyo 1628666, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2023年 / 374卷

关键词：

Biomarker; Cerebrospinal fluid; Immune checkpoint inhibitor; Immune-related adverse event; Melanoma; Peripheral neuropathy; GUILLAIN-BARRE-SYNDROME; SOLUBLE INTERLEUKIN-2-RECEPTOR; ADVERSE EVENTS; BIOMARKER; CRITERIA; MELANOMA; SERUM;

D O I：

10.1016/j.jneuroim.2022.578010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although immune checkpoint inhibitors (ICIs) are widely used to treat unresectable malignant tumors, they can cause undesirable side effects called immune-related adverse events, including neurological toxicities. Here, we describe a case of ICI-related peripheral neuropathy (irPN) with characteristic cerebrospinal fluid (CSF) findings. In addition to pleocytosis and increased protein levels, the present case showed increased levels of CSF soluble interleukin-2 receptor (sIL-2R), IL-6, and IL-10, suggesting activated T cell-related autoimmunity. We believe that CSF cytokines and sIL-2R could be novel biomarkers of irPN.

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页数：4

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