Cytotoxic phenyl polyketides from Hypericum curvisepalum N. Robson

被引：1

作者：

He, Qiu-Ying ^{[1
]}

Zeng, Hong ^{[1
]}

Zhang, Qiu-Lan ^{[2
]}

Qin, Guan-Fang ^{[2
]}

Wang, He-Bin ^{[3
]}

Teng, Li-Ping ^{[2
]}

Zhou, Zhong-Bo ^{[1
,2
,4
]}

机构：

[1] Youjiang Med Univ Nationalities, Res Ctr Prevent & Treatment Drug Resistant Microbi, Baise, Peoples R China

[2] Youjiang Med Univ Nationalities, Sch Pharm, Baise, Peoples R China

[3] Tianshui Normal Univ, Coll Chem Engn & Technol, Tianshui, Peoples R China

[4] Guangxi Database Construction & Applicat Engn Res, Baise, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 22期

基金：

中国国家自然科学基金;

关键词：

Phenyl polyketides; Hypericum curvisepalum; cytotoxicity; GENUS; CONSTITUENTS;

D O I：

10.1080/14786419.2022.2155820

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

(+/-)-Hypecurvone A (1) and B (2), two new undescribed phenyl polyketides, along with seven known analogues (3-9) were isolated from the whole plant of Hypericum curvisepalum. Chiral separation of 1 and 2 yielded two pairs of enantiomers 1a/1b and 2a/2b, respectively. The structures of these compounds were elucidated by extensive spectroscopic analyses and ECD spectra simulations. All isolates exhibited moderate cytotoxicity against human hepatocellular carcinoma SMMC-7721 cells, and compound 3 also showed weak cytotoxicity toward MGC-803 cells. The cytotoxicity of these compounds was found to be related to enhanced mitochondria-mediated apoptosis and inhibition of the G2/M phase of the cell cycle.

引用

页码：3815 / 3820

页数：6

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