Hyperforin: A natural lead compound with multiple pharmacological activities

被引：22

作者：

Li, Xin-Xin ^{[1
,2
,3
,4
]}

Yan, Yu ^{[1
,2
]}

Zhang, Jia ^{[3
,4
]}

Ding, Kang ^{[3
,4
]}

Xia, Cong-Yuan ^{[1
,2
]}

Pan, Xue-Ge ^{[3
,4
]}

Shi, Yan-Jing ^{[3
,4
]}

Xu, Jie-Kun ^{[3
,4
]}

He, Jun ^{[1
,2
]}

Zhang, Wei-Ku ^{[1
,2
]}

机构：

[1] China Japan Friendship Hosp, Inst Clin Med Sci, Beijing 100029, Peoples R China

[2] China Japan Friendship Hosp, Dept Pharm, Beijing 100029, Peoples R China

[3] Beijing Univ Chinese Med, Sch Life Sci, Beijing 100029, Peoples R China

[4] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China

来源：

PHYTOCHEMISTRY | 2023年 / 206卷

基金：

中国国家自然科学基金;

关键词：

Hypericum perforatum; Clusiaceae; Hyperforin; Detection methods; Pharmacological activities; Pharmacokinetics; Synthesis; ST-JOHNS-WORT; PERFORMANCE LIQUID-CHROMATOGRAPHY; HYPERICUM-PERFORATUM-L; LYMPHOCYTIC-LEUKEMIA CELLS; C6 GLIOBLASTOMA CELLS; IN-VITRO; MASS-SPECTROMETRY; ANTIDEPRESSANT HYPERFORIN; ALZHEIMERS-DISEASE; HUMAN PLASMA;

D O I：

10.1016/j.phytochem.2022.113526

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hypericum perforatum L. (Clusiaceae), commonly known as St. John's wort, has a rich historical background as one of the oldest and most widely studied herbal medicines. Hyperforin is the main antidepressant active ingredient of St. John's wort. In recent years, hyperforin has attached increasing attention due to its multiple pharmacological activities. In this review, the information on hyperforin was systematically summarized. Hyperforin is considered to be a lead compound with diverse pharmacological activities including anti -depression, anti-tumor, anti-dementia, anti-diabetes and others. It can be obtained by extraction and synthe-sis. Further pharmacological studies and more precise detection methods will help develop a value for hyper-forin. In addition, structural modification and pharmaceutical preparation technology will be beneficial to promoting the research progress of hyperforin based innovative drugs. Although these works are full of known and unknown challenges, researchers are still expected to make hyperforin play a greater value.

引用

页数：20