The Critical Role of RNA m6A Methylation in Gliomas: Targeting the Hallmarks of Cancer

Gliomas are the most common central cancer with high aggressive-capacity and poor prognosis, remaining to be the threat of most patients. With the blood-brain barrier and highly malignant progression, the efficacy of high-intensity treatment is limited. The N6-methyladenine (m(6)A) modification is found in rRNA, snRNA, miRNA, lncRNA, and mRNA, influencing the metabolism and translation of these RNAs and consequently regulating the proliferation, metastasis, apoptosis, etc. of glioma cells. The key role that m(6)A modification in gliomas has played makes it a prospective target for diagnosis and treatment. However, with studying deeper in m(6)A modification and gliomas, the conclusion and mechanism are abundant and complex. This review focused on the dysregulation of m(6)A regulators and m(6)A modification of key genes and pathways in Hallmarks of gliomas. Furthermore, the potential of exploiting m(6)A modification for gliomas diagnosis and therapeutics was also discussed. This review will summarize the recent studies about m(6)A modification, revealing that m(6)A modification plays an important role in the malignant progression, angiogenesis, microenvironment, and genome instability in gliomas by exploring the interaction and network between m(6)A modification-related regulators and classical tumor-related genes. And it might provide some clue for the molecular mechanism, diagnosis, and treatment of gliomas. [GRAPHICS] .