Electrospinning of chitosan-based nanofibers: from design to prospective applications

Chitosan is a biopolymer originating from renewable resources, with great properties which make it an attractive candidate for plenty of applications of contemporary interest. By manufacturing chitosan into nanofibers using the electrospinning method, its potential is amplified due to the enhancement of the active surface and the low preparation cost. Many attempts were made with the aim of preparing chitosan-based nanofibers with controlled morphology targeting their use for tissue engineering, wound healing, food packaging, drug delivery, air and water purification filters. This was a challenging task, which resulted in a high amount of data, sometimes with apparent contradictory results. In this light, the goal of the paper is to present the main routes reported in the literature for chitosan electrospinning, stressing the advantages and disadvantages of each of them. Special emphasis is placed on the influence of various electrospinning parameters on the morphological characteristics of the fibers and their suitability for distinct applications.