Association Between Severity of COVID-19 Respiratory Disease and Risk of Obstructive Sleep Apnea

被引：8

作者：

Iannella, Giannicola ^{[1
]}

Vicini, Claudio ^{[1
,2
]}

Lechien, Jerome R. ^{[3
]}

Ravaglia, Claudia ^{[4
]}

Poletti, Venerino ^{[4
,5
]}

di Cesare, Simona ^{[6
]}

Amicarelli, Elena ^{[6
]}

Gardelli, Lucia ^{[6
]}

Grosso, Carmela ^{[7
]}

Patacca, Aria ^{[7
]}

Magistrelli, Eleonora ^{[7
]}

De Benedetto, Michele ^{[8
]}

Toraldo, Domenico Maurizio ^{[9
]}

Arigliani, Michele ^{[8
]}

Cammaroto, Giovanni ^{[2
]}

Meccariello, Giuseppe ^{[2
]}

De Vito, Andrea ^{[10
]}

Magliulo, Giuseppe ^{[11
]}

Greco, Antonio ^{[11
]}

de Vincentiis, Marco ^{[11
]}

Ralli, Massimo ^{[11
]}

Pace, Annalisa ^{[11
]}

Montincone, Valentina ^{[12
]}

Maniaci, Antonino ^{[13
]}

Cocuzza, Salvatore ^{[13
]}

Seligardi, Matteo ^{[14
]}

di Giacinto, Ida ^{[15
]}

Corso, Ruggero Massimo ^{[16
]}

机构：

[1] Morgagni Pierantoni Hosp, Otolaryngol Head Neck & Oral Surg Unit, Dept Head Neck Surg, Forli, Italy

[2] Univ Ferrara, Dept ENT & Audiol, Ferrara, Italy

[3] Univ Mons UMONS, Fac Med, Lab Anat & Cell Biol, Mons, Belgium

[4] GB Morgagni L Pierantoni Hosp, Thorac Dis Dept, Pulmonol Unit, Forli, Italy

[5] Aarhus Univ Hosp, Dept Resp Dis & Allergy, Aarhus, Denmark

[6] GB Morgagni L Pierantoni Hosp, Med Dept, Forli, Italy

[7] GB Morgagni L Pierantoni Hosp, Dept Infect Dis, Forli, Italy

[8] ASL Lecce, V Fazzi Hosp, ENT Unit, Lecce, Italy

[9] ASL Lecce, Hosp Rehabil Dept, Cardioresp Care Unit, Lecce, Italy

[10] Osped Santa Maria Croci, Dept Head Neck Surg, Otolaryngol Head Neck & Oral Surg Unit, Viale Vincenzo Randi, Ravenna, Italy

[11] Univ Sapienza, Dept Organi Senso, Rome, Italy

[12] Azienda Sanit Locale CN2, Otolaryngol Dept, Alba, Italy

[13] Univ Catania, Dept Med & Surg Sci & Adv Technol GF Ingrassia, ENT Sect, Catania, Italy

[14] Azienda Unit Sanit Locale IRCCS Reggio, Infect Dis Unit, Emilia, Italy

[15] Azienda Osped Univ, St Orsola Malpighi Alma Mater Studiorum, Anesthesia & Intens Care, Anestesia & Terapia Intens Polivalente, Bologna, Italy

[16] AUSL Romagna, Morgagni Pierantoni Hosp, Intens Care Unit, Forli, Italy

来源：

ENT-EAR NOSE & THROAT JOURNAL | 2024年 / 103卷 / 01期

关键词：

obstructive sleep apnea; COVID-19; infection; respiratory disease; EXHALED NITRIC-OXIDE; EOSINOPHILIC CHRONIC RHINOSINUSITIS; ENDOSCOPIC SINUS SURGERY; AIRWAY INFLAMMATION; CLINICAL-FEATURES; ASTHMA; MANAGEMENT; DIAGNOSIS;

D O I：

10.1177/01455613211029783

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Objectives: The purpose of this observational retrospective study was to evaluate, in patients with a severe acute respiratory syndrome coronavirus 2 infection, the association between the severity of coronavirus disease 2019 (COVID-19) respiratory illness and the risk of infected patients to develop obstructive sleep apnea (OSA). Methods: Ninety-six patients with confirmed COVID-19 infection were enrolled in the study. The STOP-BANG questionnaire to investigate the risk of the OSA syndrome was filled in by the patients at admission. The enrolled patients were divided into 2 groups according to the respiratory disease: group 1 (72 patients), hospitalized patients undergoing conventional oxygen therapy; group 2 (24 patients), patients requiring enhanced respiratory support. STOP-BANG results of these 2 groups were compared to observe whether patients with high OSA risk more frequently presented a severe form of COVID-19. Results: 41.6% of the patients in group 2 had a STOP-BANG score between 5 and 8 (high risk of having apnea); in contrast, 20.8% of the patients in group 1 had a STOP-BANG score between 5 and 8, with a statistically significant difference between the 2 groups (P = .05). A complementary trend was observed regarding the proportion of patients in the range 0 to 2, which classifies patients at a low risk of OSA (48.6% vs 20.8% for groups 1 and 2, P = .01). Conclusions: According to our data, the chances of having a severe case of COVID-19 should be considered in patients at high risk of OSA. Current Knowledge/Study Rationale: Emerging research suggests that OSA could represent a potentially important risk factor for the severe forms of COVID-19. The purpose of this observational retrospective study was to evaluate the potential association between OSA and the severity of COVID-19 disease. Study Impact: According to our data, the likelihood of contracting a severe form of COVID-19 disease should be considered in patients at high risk of OSA.

引用

页码：NP10 / NP15

页数：6

共 31 条

[1]

[Anonymous], 2020, LANCET, V396, P1941, DOI 10.1016/S0140-6736(20)32709-4

[2] Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State [J].

Arentz, Matt ;

Yim, Eric ;

Klaff, Lindy ;

Lokhandwala, Sharukh ;

Riedo, Francis X. ;

Chong, Maria ;

Lee, Melissa .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (16) :1612-1614

[3] Covid-19 in Critically Ill Patients in the Seattle Region - Case Series [J].

Bhatraju, Pavan K. ;

Ghassemieh, Bijan J. ;

Nichols, Michelle ;

Kim, Richard ;

Jerome, Keith R. ;

Nalla, Arun K. ;

Greninger, Alexander L. ;

Pipavath, Sudhakar ;

Wurfel, Mark M. ;

Evans, Laura ;

Kritek, Patricia A. ;

West, T. Eoin ;

Luks, Andrew ;

Gerbino, Anthony ;

Dale, Chris R. ;

Goldman, Jason D. ;

O'Mahony, Shane ;

Mikacenic, Carmen .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (21) :2012-2022

[4] Prognostic factors and predictors of outcome in patients with COVID-19 and related pneumonia: a retrospective cohort study [J].

Boari, Gianluca E. M. ;

Chiarini, Giulia ;

Bonetti, Silvia ;

Malerba, Paolo ;

Bianco, Gianluca ;

Faustini, Cristina ;

Braglia-Orlandini, Federico ;

Turini, Daniele ;

Guarinoni, Vittoria ;

Saottini, Michele ;

Viola, Sara ;

Ferrari-Toninelli, Giulia ;

Pasini, Giancarlo ;

Mascadri, Cristina ;

Bonzi, Bianca ;

Desenzani, Paolo ;

Tusi, Claudia ;

Zanotti, Eros ;

Nardin, Matteo ;

Rizzoni, Damiano .

BIOSCIENCE REPORTS, 2020, 40

[5] Diagnostic accuracy of the Berlin questionnaire, STOP-BANG, STOP, and Epworth sleepiness scale in detecting obstructive sleep apnea: A bivariate meta-analysis [J].

Chiu, Hsiao-Yean ;

Chen, Pin-Yuan ;

Chuang, Li-Pang ;

Chen, Ning-Hung ;

Tu, Yu-Kang ;

Hsieh, Yu-Jung ;

Wang, Yu-Chi ;

Guilleminault, Christian .

SLEEP MEDICINE REVIEWS, 2017, 36 :57-70

[6] STOP-Bang Questionnaire A Practical Approach to Screen for Obstructive Sleep Apnea [J].

Chung, Frances ;

Abdullah, Hairil R. ;

Liao, Pu .

CHEST, 2016, 149 (03) :631-638

[7]

Corso RM, 2014, MINERVA ANESTESIOL, V80, P877

[8] Perioperative management of obstructive sleep apnea: a systematic review [J].

Corso, Ruggero ;

Russotto, Vincenzo ;

Gregoretti, Cesare ;

Cattano, Davide .

MINERVA ANESTESIOLOGICA, 2018, 84 (01) :81-93

[9] Phenotypes of Obstructive Sleep Apnea [J].

Coughlin, Kevin ;

Davies, George M. ;

Gillespie, Marion Boyd .

OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA, 2020, 53 (03) :329-+

[10] Obstructive sleep apnea and risk of COVID-19 infection, hospitalization and respiratory failure [J].

de Kruif, M. D. ;

Voncken, S. F. J. ;

Laven, S. A. J. S. ;

Feron, T. M. H. ;

Kolfoort-Otte, A. A. B. .

SLEEP AND BREATHING, 2021, 25 (04) :2103-2103

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