Lipids as mediators of cancer progression and metastasis

被引：45
作者：
Vogel, Felix C. E. [1 ,2 ]
Chaves-Filho, Adriano B. [1 ,2 ,3 ]
Schulze, Almut [1 ,2 ]
机构：
[1] German Canc Res Ctr, Div Tumor Metab & Microenvironm, Heidelberg, Germany
[2] DKFZ ZMBH Alliance, Heidelberg, Germany
[3] Univ Sao Paulo, Inst Chem, Sao Paulo, Brazil
来源：
NATURE CANCER | 2024年 / 5卷 / 01期
基金：
巴西圣保罗研究基金会;
关键词：
FATTY-ACID OXIDATION; RENAL-CELL CARCINOMA; TUMOR-GROWTH; METABOLISM; FERROPTOSIS; DRUG; ACTIVATION; HALLMARKS; SYNTHASE; PATHWAY;
D O I：
10.1038/s43018-023-00702-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Metastasis formation is a complex process, involving multiple crucial steps, which are controlled by different regulatory mechanisms. In this context, the contribution of cancer metabolism to the metastatic cascade is being increasingly recognized. This Review focuses on changes in lipid metabolism that contribute to metastasis formation in solid tumors. We discuss the molecular mechanisms by which lipids induce a pro-metastatic phenotype and explore the role of lipids in response to oxidative stress and as signaling molecules. Finally, we reflect on potential avenues to target lipid metabolism to improve the treatment of metastatic cancers. Schulze and colleagues discuss the latest advances in understanding the role of lipids in cancer progression and metastasis and reflect on opportunities to target lipid metabolism in tumors.
引用
收藏
页码：16 / 29
页数：14
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