Lipids as mediators of cancer progression and metastasis

被引:33
作者
Vogel, Felix C. E. [1 ,2 ]
Chaves-Filho, Adriano B. [1 ,2 ,3 ]
Schulze, Almut [1 ,2 ]
机构
[1] German Canc Res Ctr, Div Tumor Metab & Microenvironm, Heidelberg, Germany
[2] DKFZ ZMBH Alliance, Heidelberg, Germany
[3] Univ Sao Paulo, Inst Chem, Sao Paulo, Brazil
基金
巴西圣保罗研究基金会;
关键词
FATTY-ACID OXIDATION; RENAL-CELL CARCINOMA; TUMOR-GROWTH; METABOLISM; FERROPTOSIS; DRUG; ACTIVATION; HALLMARKS; SYNTHASE; PATHWAY;
D O I
10.1038/s43018-023-00702-z
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Metastasis formation is a complex process, involving multiple crucial steps, which are controlled by different regulatory mechanisms. In this context, the contribution of cancer metabolism to the metastatic cascade is being increasingly recognized. This Review focuses on changes in lipid metabolism that contribute to metastasis formation in solid tumors. We discuss the molecular mechanisms by which lipids induce a pro-metastatic phenotype and explore the role of lipids in response to oxidative stress and as signaling molecules. Finally, we reflect on potential avenues to target lipid metabolism to improve the treatment of metastatic cancers. Schulze and colleagues discuss the latest advances in understanding the role of lipids in cancer progression and metastasis and reflect on opportunities to target lipid metabolism in tumors.
引用
收藏
页码:16 / 29
页数:14
相关论文
共 181 条
[61]   A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: the ERGO (etomoxir for the recovery of glucose oxidation) study [J].
Holubarsch, Christian J. F. ;
Rohrbach, Martin ;
Karrasch, Matthias ;
Boehm, Erich ;
Polonski, Lech ;
Ponikowski, Piotr ;
Rhein, Siegfried .
CLINICAL SCIENCE, 2007, 113 (3-4) :205-212
[62]   HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression [J].
Huang, De ;
Li, Tingting ;
Li, Xinghua ;
Zhang, Long ;
Sun, Linchong ;
He, Xiaoping ;
Zhong, Xiuying ;
Jia, Dongya ;
Song, Libing ;
Semenza, Gregg L. ;
Gao, Ping ;
Zhang, Huafeng .
CELL REPORTS, 2014, 8 (06) :1930-1942
[63]   Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts [J].
Huang, Yung-Chi ;
Hou, Ming-Feng ;
Tsai, Ying-Ming ;
Pan, Yi-Chung ;
Tsai, Pei-Hsun ;
Lin, Yi-Shiuan ;
Chang, Chao-Yuan ;
Tsai, Eing-Mei ;
Hsu, Ya-Ling .
CELLULAR ONCOLOGY, 2023, 46 (03) :643-660
[64]   Ct-OATP1B3 promotes high-grade serous ovarian cancer metastasis by regulation of fatty acid beta-oxidation and oxidative phosphorylation [J].
Huang, Yutang ;
Du, Yan ;
Zheng, Yujie ;
Wen, Chunjie ;
Zou, Hecun ;
Huang, Jiafeng ;
Zhou, Honghao ;
Zhao, Hongbo ;
Wu, Lanxiang .
CELL DEATH & DISEASE, 2022, 13 (06)
[65]   Mechanism and significance of increased glutathione level in human hepatocellular carcinoma and liver regeneration [J].
Huang, ZZ ;
Chen, CJ ;
Zeng, ZH ;
Yang, HP ;
Oh, J ;
Chen, LX ;
Lu, SC .
FASEB JOURNAL, 2001, 15 (01) :19-21
[66]   Intratumor heterogeneity reflects clinical disease course [J].
Iacobuzio-Donahue, Christine A. ;
Litchfield, Kevin ;
Swanton, Charles .
NATURE CANCER, 2020, 1 (01) :3-6
[67]   Ferroptosis: mechanisms, biology and role in disease [J].
Jiang, Xuejun ;
Stockwell, Brent R. ;
Conrad, Marcus .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2021, 22 (04) :266-282
[68]   A metastasis map of human cancer cell lines [J].
Jin, Xin ;
Demere, Zelalem ;
Nair, Karthik ;
Ali, Ahmed ;
Ferraro, Gino B. ;
Natoli, Ted ;
Deik, Amy ;
Petronio, Lia ;
Tang, Andrew A. ;
Zhu, Cong ;
Wang, Li ;
Rosenberg, Danny ;
Mangena, Vamsi ;
Roth, Jennifer ;
Chung, Kwanghun ;
Jain, Rakesh K. ;
Clish, Clary B. ;
Heiden, Matthew G. Vander ;
Golub, Todd R. .
NATURE, 2020, 588 (7837) :331-+
[69]  
Kagan VE, 2017, NAT CHEM BIOL, V13, P81, DOI [10.1038/NCHEMBIO.2238, 10.1038/nchembio.2238]
[70]   Spheroid-Induced Epithelial-Mesenchymal Transition Provokes Global Alterations of Breast Cancer Lipidome: A Multi-Layered Omics Analysis [J].
Kang, Yun Pyo ;
Yoon, Jung-Ho ;
Nguyen Phuoc Long ;
Koo, Gi-Bang ;
Noh, Hyun-Jin ;
Oh, Seung-Jae ;
Lee, Sae Bom ;
Kim, Hyung Min ;
Hong, Ji Yeon ;
Lee, Won Jun ;
Lee, Seul Ji ;
Hong, Soon-Sun ;
Kwon, Sung Won ;
Kim, You-Sun .
FRONTIERS IN ONCOLOGY, 2019, 9