Lipids as mediators of cancer progression and metastasis

被引：45

作者：

Vogel, Felix C. E. ^{[1
,2
]}

Chaves-Filho, Adriano B. ^{[1
,2
,3
]}

Schulze, Almut ^{[1
,2
]}

机构：

[1] German Canc Res Ctr, Div Tumor Metab & Microenvironm, Heidelberg, Germany

[2] DKFZ ZMBH Alliance, Heidelberg, Germany

[3] Univ Sao Paulo, Inst Chem, Sao Paulo, Brazil

来源：

NATURE CANCER | 2024年 / 5卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

FATTY-ACID OXIDATION; RENAL-CELL CARCINOMA; TUMOR-GROWTH; METABOLISM; FERROPTOSIS; DRUG; ACTIVATION; HALLMARKS; SYNTHASE; PATHWAY;

D O I：

10.1038/s43018-023-00702-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastasis formation is a complex process, involving multiple crucial steps, which are controlled by different regulatory mechanisms. In this context, the contribution of cancer metabolism to the metastatic cascade is being increasingly recognized. This Review focuses on changes in lipid metabolism that contribute to metastasis formation in solid tumors. We discuss the molecular mechanisms by which lipids induce a pro-metastatic phenotype and explore the role of lipids in response to oxidative stress and as signaling molecules. Finally, we reflect on potential avenues to target lipid metabolism to improve the treatment of metastatic cancers. Schulze and colleagues discuss the latest advances in understanding the role of lipids in cancer progression and metastasis and reflect on opportunities to target lipid metabolism in tumors.

引用

页码：16 / 29

页数：14

共 181 条

[31] Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing [J].

Davis, Ryan T. ;

Blake, Kerrigan ;

Ma, Dennis ;

Gabra, Mari B. Ishak ;

Hernandez, Grace A. ;

Phung, Anh T. ;

Yang, Ying ;

Maurer, Dustin ;

Lefebvre, Austin E. Y. T. ;

Alshetaiwi, Hamad ;

Xiao, Zhengtao ;

Liu, Juan ;

Locasale, Jason W. ;

Digman, Michelle A. ;

Mjolsness, Eric ;

Kong, Mei ;

Werb, Zena ;

Lawson, Devon A. .

NATURE CELL BIOLOGY, 2020, 22 (03) :310-+

[32] Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion [J].

Dirat, Beatrice ;

Bochet, Ludivine ;

Dabek, Marta ;

Daviaud, Daniele ;

Dauvillier, Stephanie ;

Majed, Bilal ;

Wang, Yuan Yuan ;

Meulle, Aline ;

Salles, Bernard ;

Le Gonidec, Sophie ;

Garrido, Ignacio ;

Escourrou, Ghislaine ;

Valet, Philippe ;

Muller, Catherine .

CANCER RESEARCH, 2011, 71 (07) :2455-2465

[33] The Hallmarks of Ferroptosis [J].

Dixon, Scott J. ;

Stockwell, Brent R. .

ANNUAL REVIEW OF CANCER BIOLOGY, VOL 3, 2019, 3 :35-54

[34] Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death [J].

Dixon, Scott J. ;

Lemberg, Kathryn M. ;

Lamprecht, Michael R. ;

Skouta, Rachid ;

Zaitsev, Eleina M. ;

Gleason, Caroline E. ;

Patel, Darpan N. ;

Bauer, Andras J. ;

Cantley, Alexandra M. ;

Yang, Wan Seok ;

Morrison, Barclay, III ;

Stockwell, Brent R. .

CELL, 2012, 149 (05) :1060-1072

[35] FSP1 is a glutathione-independent ferroptosis suppressor [J].

Doll, Sebastian ;

Freitas, Florencio Porto ;

Shah, Ron ;

Aldrovandi, Maceler ;

da Silva, Milene Costa ;

Ingold, Irina ;

Grocin, Andrea Goya ;

da Silva, Thamara Nishida Xavier ;

Panzilius, Elena ;

Scheel, Christina H. ;

Mourao, Andre ;

Buday, Katalin ;

Sato, Mami ;

Wanninger, Jonas ;

Vignane, Thibaut ;

Mohana, Vaishnavi ;

Rehberg, Markus ;

Flatley, Andrew ;

Schepers, Aloys ;

Kurz, Andreas ;

White, Daniel ;

Sauer, Markus ;

Sattler, Michael ;

Tate, Edward William ;

Schmitz, Werner ;

Schulze, Almut ;

O'Donnell, Valerie ;

Proneth, Bettina ;

Popowicz, Grzegorz M. ;

Pratt, Derek A. ;

Angeli, Jose Pedro Friedmann ;

Conrad, Marcus .

NATURE, 2019, 575 (7784) :693-+

[36]

Doll S, 2017, NAT CHEM BIOL, V13, P91, DOI [10.1038/NCHEMBIO.2239, 10.1038/nchembio.2239]

[37] Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis [J].

Dorsch, Madeleine ;

Kowalczyk, Manuela ;

Planque, Melanie ;

Heilmann, Geronimo ;

Urban, Sebastian ;

Dujardin, Philip ;

Forster, Jan ;

Ueffing, Kristina ;

Nothdurft, Silke ;

Oeck, Sebastian ;

Paul, Annika ;

Liffers, Sven T. ;

Kaschani, Farnusch ;

Kaiser, Markus ;

Schramm, Alexander ;

Siveke, Jens T. ;

Winslow, Monte M. ;

Fendt, Sarah-Maria ;

Nalbant, Perihan ;

Gruener, Barbara M. .

CELL REPORTS, 2021, 37 (08)

[38] FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis [J].

Du, Qiqiao ;

Liu, Pan ;

Zhang, Chunyu ;

Liu, Tianyu ;

Wang, Wei ;

Shang, Chunliang ;

Wu, Jieyu ;

Liao, Yuandong ;

Chen, Yili ;

Huang, Jiaming ;

Tan, Hao ;

Zhao, Yunhe ;

Xia, Meng ;

Liu, Junxiu ;

Yao, Shuzhong .

CELL DEATH & DISEASE, 2022, 13 (05)

[39] Metabolic Hallmarks of Metastasis Formation [J].

Elia, Ilaria ;

Doglioni, Ginevra ;

Fendt, Sarah-Maria .

TRENDS IN CELL BIOLOGY, 2018, 28 (08) :673-684

[40] Disruption of Prostaglandin E2 Signaling in Cancer-Associated Fibroblasts Limits Mammary Carcinoma Growth but Promotes Metastasis [J].

Elwakeel, Eiman ;

Brueggemann, Mirko ;

Wagih, Jessica ;

Lityagina, Olga ;

Elewa, Mohammed A. F. ;

Han, Yingying ;

Froemel, Timo ;

Popp, Ruediger ;

Nicolas, Adele M. ;

Schreiber, Yannick ;

Gradhand, Elise ;

Thomas, Dominique ;

Nuesing, Rolf ;

Steinmetz-Spaeh, Julia ;

Savai, Rajkumar ;

Fokas, Emmanouil ;

Fleming, Ingrid ;

Greten, Florian R. ;

Zarnack, Kathi ;

Bruene, Bernhard ;

Weigert, Andreas .

CANCER RESEARCH, 2022, 82 (07) :1380-1395

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