Lipids as mediators of cancer progression and metastasis

被引：33

作者：

Vogel, Felix C. E. ^{[1
,2
]}

Chaves-Filho, Adriano B. ^{[1
,2
,3
]}

Schulze, Almut ^{[1
,2
]}

机构：

[1] German Canc Res Ctr, Div Tumor Metab & Microenvironm, Heidelberg, Germany

[2] DKFZ ZMBH Alliance, Heidelberg, Germany

[3] Univ Sao Paulo, Inst Chem, Sao Paulo, Brazil

来源：

NATURE CANCER | 2024年 / 5卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

FATTY-ACID OXIDATION; RENAL-CELL CARCINOMA; TUMOR-GROWTH; METABOLISM; FERROPTOSIS; DRUG; ACTIVATION; HALLMARKS; SYNTHASE; PATHWAY;

D O I：

10.1038/s43018-023-00702-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastasis formation is a complex process, involving multiple crucial steps, which are controlled by different regulatory mechanisms. In this context, the contribution of cancer metabolism to the metastatic cascade is being increasingly recognized. This Review focuses on changes in lipid metabolism that contribute to metastasis formation in solid tumors. We discuss the molecular mechanisms by which lipids induce a pro-metastatic phenotype and explore the role of lipids in response to oxidative stress and as signaling molecules. Finally, we reflect on potential avenues to target lipid metabolism to improve the treatment of metastatic cancers. Schulze and colleagues discuss the latest advances in understanding the role of lipids in cancer progression and metastasis and reflect on opportunities to target lipid metabolism in tumors.

引用

页码：16 / 29

页数：14

共 181 条

[1] Fatty acid transport proteins (FATPs) in cancer [J].

Acharya, Ranjitha ;

Shetty, Shilpa S. ;

Kumari, N. Suchetha .

CHEMISTRY AND PHYSICS OF LIPIDS, 2023, 250

[2] A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors [J].

Aloia, Andrea ;

Mullhaupt, Daniela ;

Chabbert, Christophe D. ;

Eberhart, Tanja ;

Fluckiger-Mangual, Stefanie ;

Vukolic, Ana ;

Eichhoff, Ossia ;

Irmisch, Anja ;

Alexander, Leila T. ;

Scibona, Ernesto ;

Frederick, Dennie T. ;

Miao, Benchun ;

Tian, Tian ;

Cheng, Chaoran ;

Kwong, Lawrence N. ;

Wei, Zhi ;

Sullivan, Ryan J. ;

Boland, Genevieve M. ;

Herlyn, Meenhard ;

Flaherty, Keith T. ;

Zamboni, Nicola ;

Dummer, Reinhard ;

Zhang, Gao ;

Levesque, Mitchell P. ;

Krek, Wilhelm ;

Kovacs, Werner J. .

CLINICAL CANCER RESEARCH, 2019, 25 (22) :6852-6867

[3] A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling [J].

Altea-Manzano, Patricia ;

Doglioni, Ginevra ;

Liu, Yawen ;

Cuadros, Alejandro M. ;

Nolan, Emma ;

Fernandez-Garcia, Juan ;

Wu, Qi ;

Planque, Melanie ;

Laue, Kathrin Julia ;

Cidre-Aranaz, Florencia ;

Liu, Xiao-Zheng ;

Marin-Bejar, Oskar ;

Van Elsen, Joke ;

Vermeire, Ines ;

Broekaert, Dorien ;

Demeyer, Sofie ;

Spotbeen, Xander ;

Idkowiak, Jakub ;

Montagne, Aurelie ;

Demicco, Margherita ;

Alkan, H. Furkan ;

Rabas, Nick ;

Riera-Domingo, Carla ;

Richard, Francois ;

Geukens, Tatjana ;

De Schepper, Maxim ;

Leduc, Sophia ;

Hatse, Sigrid ;

Lambrechts, Yentl ;

Kay, Emily Jane ;

Lilla, Sergio ;

Alekseenko, Alisa ;

Geldhof, Vincent ;

Boeckx, Bram ;

de la Calle Arregui, Celia ;

Floris, Giuseppe ;

Swinnen, Johannes V. ;

Marine, Jean-Christophe ;

Lambrechts, Diether ;

Pelechano, Vicent ;

Mazzone, Massimiliano ;

Zanivan, Sara ;

Cools, Jan ;

Wildiers, Hans ;

Baud, Veronique ;

Gruenewald, Thomas G. P. ;

Ben-David, Uri ;

Desmedt, Christine ;

Malanchi, Ilaria ;

Fendt, Sarah-Maria .

NATURE CANCER, 2023, 4 (03) :344-+

[4] Glutathione protects metastatic melanoma cells against oxidative stress in the murine hepatic microvasculature [J].

Anasagasti, MJ ;

Martin, JJ ;

Mendoza, L ;

Obrador, E ;

Estrela, JM ;

McCuskey, RS ;

Vidal-Vanaclocha, F .

HEPATOLOGY, 1998, 27 (05) :1249-1256

[5] Selenium and GPX4, a vital symbiosis [J].

Angeli, Jose Pedro Friedmann ;

Conrad, Marcus .

FREE RADICAL BIOLOGY AND MEDICINE, 2018, 127 :153-159

[6] Sphingosine-1-Phosphate Recruits Macrophages and Microglia and Induces a Pro-Tumorigenic Phenotype That Favors Glioma Progression [J].

Arseni, Lavinia ;

Sharma, Rakesh ;

Mack, Norman ;

Nagalla, Deepthi ;

Ohl, Sibylle ;

Hielscher, Thomas ;

Singhal, Mahak ;

Pilz, Robert ;

Augustin, Hellmut ;

Sandhoff, Roger ;

Herold-Mende, Christel ;

Tews, Bjoern ;

Lichter, Peter ;

Seiffert, Martina .

CANCERS, 2023, 15 (02)

[7] Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila [J].

Bailey, Andrew P. ;

Koster, Grielof ;

Guillermier, Christelle ;

Hirst, Elizabeth M. A. ;

MacRae, James I. ;

Lechene, Claude P. ;

Postle, Anthony D. ;

Gould, Alex P. .

CELL, 2015, 163 (02) :340-353

[8] Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1 [J].

Beatty, Alexander ;

Singh, Tanu ;

Tyurina, Yulia Y. ;

Tyurin, Vladimir A. ;

Samovich, Svetlana ;

Nicolas, Emmanuelle ;

Maslar, Kristen ;

Zhou, Yan ;

Cai, Kathy Q. ;

Tan, Yinfei ;

Doll, Sebastian ;

Conrad, Marcus ;

Subramanian, Aravind ;

Kagan, Valerian E. ;

Rennefahrt, Ulrike ;

Peterson, Jeffrey R. ;

Bayir, Hulya .

NATURE COMMUNICATIONS, 2021, 12 (01)

[9] Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations [J].

Bell, Charlotte R. ;

Pelly, Victoria S. ;

Moeini, Agrin ;

Chiang, Shih-Chieh ;

Flanagan, Eimear ;

Bromley, Christian P. ;

Clark, Christopher ;

Earnshaw, Charles H. ;

Koufaki, Maria A. ;

Bonavita, Eduardo ;

Zelenay, Santiago .

NATURE COMMUNICATIONS, 2022, 13 (01)

[10] Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation [J].

Bensaad, Karim ;

Favaro, Elena ;

Lewis, Caroline A. ;

Peck, Barrie ;

Lord, Simon ;

Collins, Jennifer M. ;

Pinnick, Katherine E. ;

Wigfield, Simon ;

Buffa, Francesca M. ;

Li, Ji-Liang ;

Zhang, Qifeng ;

Wakelam, Michael J. O. ;

Karpe, Fredrik ;

Schulze, Almut ;

Harris, Adrian L. .

CELL REPORTS, 2014, 9 (01) :349-365

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