Evaluation of Predicting Factors Affecting Sperm Retrieval in Patients with Klinefelter Syndrome: A Prospective Study

被引:0
作者
Aliakbari, Fereshteh [1 ]
Taghizabet, Neda [1 ]
Rezaei-Tazangi, Fatemeh [2 ]
Kalantari, Hamid [3 ,4 ]
Dizaj, Ahmad Vosough [3 ]
Mohammadi, Maryam [5 ]
Sajadi, Hesamoddin [3 ,4 ,6 ]
Gilani, Mohammad Ali Sadighi [3 ,4 ,6 ]
机构
[1] Shahid Beheshti Univ Med Sci, Mens Hlth & Reprod Hlth Res Ctr, Tehran, Iran
[2] Fasa Univ Med Sci, Sch Med, Dept Anat, Fasa, Iran
[3] Royan Inst Reprod Biomed, ACECR, Reprod Biomed Res Ctr, Dept Androl, Tehran, Iran
[4] Univ Tehran Med Sci, Dept Urol, Shariati Hosital, Tehran, Iran
[5] Royan Inst Reprod Biomed, Reprod Epidemiol Res Ctr, ACECR, Tehran, Iran
[6] Royan Inst Reprod Biomed, Reprod Biomed Res Ctr, Dept Androl, ACECR, POB 16635-148, Tehran, Iran
关键词
Azoospermic; Klinefelter; Testicular Sperm Extraction; Ultrasonography; MALE-INFERTILITY; ULTRASOUND; MEN; SONOGRAPHY; RECOVERY;
D O I
10.22074/IJFS.2023.562534.1371
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Background: This study aimed to evaluate the predicting factors affecting sperm retrieval. We prospectively assessed the relationship between sonographic and microdissection testicular sperm extraction (mTESE) findings in Klinefelter syndrome (KS). Materials and Methods: In this prospective study, 44 azoospermic men with 47, XXY karyotypes participated in this study. In order to evaluate the amount of blood supply in different parts of testicular tissue, a doppler ultra-sonographic was performed. Also, for the detection of sperm in this group mTESE technique was performed. Results: The age average of positive mTESE and negative mTESE groups was 29.4 and 33.6 years, respectively. By comparing the testicle volume (based on the data obtained from the clinical examinations conducted by the urologist) it was determined that there is no significant difference between mTESE positive and negative groups. Follicle stimulating hormone (FSH) levels in men with negative mTESE (P=0.03) and testosterone levels in men with positive mTESE significantly increased (P=0.017). The overall rate of testis vascularity was significantly higher in the positive mTESE group than in the negative mTESE group. The clinical pregnancy rate in positive mTESE men was 9% per cycle, 16.6% per embryos were transferred (ET), and 12.5% per cycle. Conclusion: Totally, our observation indicated that there is not a significant relationship between sonographic and mTESE results in KS patients. However, more investigations with bigger sample Size can be useful to validate our results.
引用
收藏
页码:276 / 280
页数:5
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