Anticancer properties of sulforaphane: current insights at the molecular level

被引：18

作者：

Asif Ali, Muhammad ^{[1
]}

Khan, Noohela ^{[2
]}

Kaleem, Nabeeha ^{[1
]}

Ahmad, Waqas ^{[1
]}

Alharethi, Salem Hussain ^{[3
]}

Alharbi, Bandar ^{[4
]}

Alhassan, Hassan H. ^{[5
]}

Al-Enazi, Maher M. ^{[6
]}

Razis, Ahmad Faizal Abdull ^{[7
,8
]}

Modu, Babagana ^{[8
,9
]}

Calina, Daniela ^{[10
]}

Sharifi-Rad, Javad ^{[11
]}

机构：

[1] Univ Vet & Anim Sci, Dept Food Sci & Human Nutr, Lahore, Pakistan

[2] Rashid Latif Med Coll, Dept Nutr Sci, Lahore, Pakistan

[3] Najran Univ, Coll Arts & Sci, Dept Biol Sci, Najran, Saudi Arabia

[4] Univ Hail, Coll Appl Med Sci, Dept Med Lab Sci, Hail, Saudi Arabia

[5] Jouf Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Sakaka, Saudi Arabia

[6] Prince Sattam Bin Abdulaziz Univ, Coll Appl Med Sci Al Kharj, Dept Med Lab Sci, Al Kharj, Saudi Arabia

[7] Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Sci, Serdang, Selangor, Malaysia

[8] Univ Putra Malaysia, Inst Biosci, Nat Med & Prod Res Lab, Serdang, Selangor, Malaysia

[9] Univ Maiduguri, Fac Sci, Dept Biochem, Maiduguri, Borno, Nigeria

[10] Univ Med & Pharm Craiova, Dept Clin Pharm, Craiova, Romania

[11] Univ Azuay, Fac Med, Cuenca, Ecuador

来源：

FRONTIERS IN ONCOLOGY | 2023年 / 13卷

关键词：

sulforaphane; isothiocyanate; anticancer mechanisms; cytotoxicity; apoptosis; HISTONE DEACETYLASE ACTIVITY; PHASE-II; IN-VITRO; CHEMOPREVENTIVE ACTIVITY; CANCER; PROSTATE; BROCCOLI; MEN; TARGET; CELLS;

D O I：

10.3389/fonc.2023.1168321

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli as they contain 1,153 mg/100 g. SFN is a secondary metabolite that is produced as a result of the hydrolysis of glucoraphanin (a glucosinolate) by the enzyme myrosinase. This review paper aims to summarize and understand the mechanisms behind the anticancer potential of sulforaphane. The data was collected by searching PubMed/MedLine, Scopus, Web of Science, and Google Scholar. This paper concludes that sulforaphane provides cancer protection through the alteration of various epigenetic and non-epigenetic pathways. It is a potent anticancer phytochemical that is safe to consume with minimal side effects. However, there is still a need for further research regarding SFN and the development of a standard dose.

引用

页数：9

共 50 条

[41] Anticancer properties of bromelain: State-of-the-art and recent trends
Pezzani, Raffaele
Jimenez-Garcia, Manuel
Capo, Xavier
Sonmez Gurer, Eda
Sharopov, Farukh
Rachel, Tchokouaha Yamthe Lauve
Ntieche Woutouoba, David
Rescigno, Antonio
Peddio, Stefania
Zucca, Paolo
Tsouh Fokou, Patrick Valere
Martorell, Miquel
Gulsunoglu-Konuskan, Zehra
Ydyrys, Alibek
Bekzat, Tynybekov
Gulmira, Tussupbekova
Hano, Christophe
Sharifi-Rad, Javad
Calina, Daniela
FRONTIERS IN ONCOLOGY, 2023, 12
[42] Anticancer activity of sulforaphane against human hepatoblastoma cells involves apoptosis, autophagy and inhibition of β-catenin signaling pathway
Lin, Junshan
Xu, Yali
Zhao, Xing
Qiu, Zhixin
ARCHIVES OF MEDICAL SCIENCE, 2025, 21 (02) : 658 - 666
[43] The Antioxidant Properties of Organosulfur Compounds (Sulforaphane)
de Figueiredo, Sonia M.
Binda, Nancy S.
Nogueira-Machado, Jose A.
Vieira-Filho, Sidney A.
Caligiorne, Rachel B.
RECENT PATENTS ON ENDOCRINE METABOLIC & IMMUNE DRUG DISCOVERY, 2015, 9 (01) : 24 - 39
[44] Updated aspects of alpha-Solanine as a potential anticancer agent: Mechanistic insights and future directions
Nandi, Sudeshna
Sikder, Rimpa
Nag, Anish
Khatua, Somanjana
Sen, Surjit
Chakraborty, Nilanjan
Naskar, Arghya
Zhakipbekov, Kairat
Acharya, Krishnendu
Habtemariam, Solomon
Atessahin, Dilek Arslan
Goloshvili, Tamar
Aldahish, Afaf Ahmed
Sharifi-Rad, Javad
Calina, Daniela
FOOD SCIENCE & NUTRITION, 2024, 12 (10): : 7088 - 7107
[45] Current Scenario of Acridine Hybrids with Anticancer Potential
Zhang, Qihong
Yu, Xia
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2021, 21 (19) : 1773 - 1786
[46] Current status of the molecular mechanisms of anticancer drug-induced apoptosis - The contribution of molecular-level analysis to cancer chemotherapy
Kim, R
Tanabe, K
Uchida, Y
Emi, M
Inoue, H
Toge, T
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2002, 50 (05) : 343 - 352
[47] Molecular mechanisms of sulforaphane in Alzheimer’s disease: insights from an in-silico study
Giang Huong Vu
Hai Duc Nguyen
In Silico Pharmacology, 12 (2)
[48] Molecular Docking of Lactoferrin with Apoptosis-Related Proteins Insights into Its Anticancer Mechanism
Angel-Lerma, Lidia Esmeralda
Carrillo-Campos, Javier
Sianez-Estrada, Luis Ignacio
Siqueiros-Cendon, Tania Samanta
Leon-Flores, Dyada Blanca
Espinoza-Sanchez, Edward Alexander
Arevalo-Gallegos, Sigifredo
Iglesias-Figueroa, Blanca Flor
Rascon-Cruz, Quintin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 26 (05)
[49] Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway
Su, Xuling
Jiang, Xin
Meng, Lingbin
Dong, Xiaoming
Shen, Yanjun
Xin, Ying
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018, 2018
[50] Anticancer mechanisms of metformin: A review of the current evidence
Zhao, Bin
Luo, Jie
Yu, Tongyao
Zhou, Liangfu
Lv, Huanhuan
Shang, Peng
LIFE SCIENCES, 2020, 254

← 1 2 3 4 5 →