Anticancer properties of sulforaphane: current insights at the molecular level

被引：18
|
作者：
Asif Ali, Muhammad [1 ]
Khan, Noohela [2 ]
Kaleem, Nabeeha [1 ]
Ahmad, Waqas [1 ]
Alharethi, Salem Hussain [3 ]
Alharbi, Bandar [4 ]
Alhassan, Hassan H. [5 ]
Al-Enazi, Maher M. [6 ]
Razis, Ahmad Faizal Abdull [7 ,8 ]
Modu, Babagana [8 ,9 ]
Calina, Daniela [10 ]
Sharifi-Rad, Javad [11 ]
机构：
[1] Univ Vet & Anim Sci, Dept Food Sci & Human Nutr, Lahore, Pakistan
[2] Rashid Latif Med Coll, Dept Nutr Sci, Lahore, Pakistan
[3] Najran Univ, Coll Arts & Sci, Dept Biol Sci, Najran, Saudi Arabia
[4] Univ Hail, Coll Appl Med Sci, Dept Med Lab Sci, Hail, Saudi Arabia
[5] Jouf Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Sakaka, Saudi Arabia
[6] Prince Sattam Bin Abdulaziz Univ, Coll Appl Med Sci Al Kharj, Dept Med Lab Sci, Al Kharj, Saudi Arabia
[7] Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Sci, Serdang, Selangor, Malaysia
[8] Univ Putra Malaysia, Inst Biosci, Nat Med & Prod Res Lab, Serdang, Selangor, Malaysia
[9] Univ Maiduguri, Fac Sci, Dept Biochem, Maiduguri, Borno, Nigeria
[10] Univ Med & Pharm Craiova, Dept Clin Pharm, Craiova, Romania
[11] Univ Azuay, Fac Med, Cuenca, Ecuador
来源：
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词：
sulforaphane; isothiocyanate; anticancer mechanisms; cytotoxicity; apoptosis; HISTONE DEACETYLASE ACTIVITY; PHASE-II; IN-VITRO; CHEMOPREVENTIVE ACTIVITY; CANCER; PROSTATE; BROCCOLI; MEN; TARGET; CELLS;
D O I：
10.3389/fonc.2023.1168321
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli as they contain 1,153 mg/100 g. SFN is a secondary metabolite that is produced as a result of the hydrolysis of glucoraphanin (a glucosinolate) by the enzyme myrosinase. This review paper aims to summarize and understand the mechanisms behind the anticancer potential of sulforaphane. The data was collected by searching PubMed/MedLine, Scopus, Web of Science, and Google Scholar. This paper concludes that sulforaphane provides cancer protection through the alteration of various epigenetic and non-epigenetic pathways. It is a potent anticancer phytochemical that is safe to consume with minimal side effects. However, there is still a need for further research regarding SFN and the development of a standard dose.
引用
收藏
页数：9
相关论文
共 50 条
  • [21] Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms
    Carla Varela
    Catarina Melim
    Beatriz G. Neves
    Javad Sharifi-Rad
    Daniela Calina
    Assem Mamurova
    Célia Cabral
    Journal of Translational Medicine, 20
  • [22] A mechanistic insight into the anticancer potentials of resveratrol: Current perspectives
    Bhuia, Md. Shimul
    Chowdhury, Raihan
    Akter, Mst. Asma
    Ali, Md. Arman
    Afroz, Meher
    Akbor, Md. Showkot
    Sonia, Fatema Akter
    Mubarak, Mohammad S.
    Islam, Muhammad Torequl
    PHYTOTHERAPY RESEARCH, 2024, 38 (08) : 3877 - 3898
  • [23] Insights on Anticancer Activities, Associated Phytochemicals and Potential Molecular Mechanisms of Quisqualis indica: A Mini Review
    Wu, Yuan Seng
    Lee, Michelle Felicia
    Mac Guad, Rhanye
    Ozeer, Fathima Zahraa
    Velaga, Appalaraju
    Subramaniyan, Vetriselvan
    Fuloria, Neeraj Kumar
    Fuloria, Shivkanya
    Choy, Ker Woon
    Lee, Sze Meng
    Gopinath, Subash C. B.
    Verma, Amita
    Lau, Tze Pheng
    SAINS MALAYSIANA, 2023, 52 (06): : 1749 - 1758
  • [24] The anticancer properties of harmine and its derivatives
    Timbilla, Abdul Aziz
    Vrabec, Rudolf
    Havelek, Radim
    Rezacova, Martina
    Chlebek, Jakub
    Blunden, Gerald
    Cahlikova, Lucie
    PHYTOCHEMISTRY REVIEWS, 2024, : 1535 - 1564
  • [25] Molecular insights into the antioxidant and anticancer properties: A comprehensive analysis through molecular modeling, docking, and dynamics studies
    Banu, Hamza Serina
    Parvin, Ismail sheriff
    Priyadharshini, Subramanian Deepika
    Gayathiri, Ekambaram
    Prakash, Palanisamy
    Pratheep, Thangaraj
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2024, 125 (10)
  • [26] Anticancer properties and mechanism insights of α-hederin
    Belmehdi, Omar
    Taha, Douae
    Abrini, Jamal
    Ming, Long Chiau
    Khalid, Asaad
    Abdalla, Ashraf N.
    Algarni, Alanood S.
    Hermansyah, Andi
    Bouyahya, Abdelhakim
    BIOMEDICINE & PHARMACOTHERAPY, 2023, 165
  • [27] Potential Anticancer Properties of Bisphosphonates: Insights From Preclinical Studies
    Clezardin, Philippe
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2012, 12 (02) : 102 - 113
  • [28] Insights about stabilization of sulforaphane through microencapsulation
    Zambrano, Victor
    Bustos, Ruben
    Mahn, Andrea
    HELIYON, 2019, 5 (11)
  • [29] Molecular Insights into the Anticancer Activity of Withaferin-A: The Inhibition of Survivin Signaling
    Wadhwa, Renu
    Wang, Jia
    Shefrin, Seyad
    Zhang, Huayue
    Sundar, Durai
    Kaul, Sunil C.
    CANCERS, 2024, 16 (17)
  • [30] In Vitro Insights into the Dietary Role of Glucoraphanin and Its Metabolite Sulforaphane in Celiac Disease
    Sonzogni, Elisa
    Martinelli, Giulia
    Fumagalli, Marco
    Maranta, Nicole
    Pozzoli, Carola
    Bani, Corinne
    Marrari, Luigi Alberto
    Di Lorenzo, Chiara
    Sangiovanni, Enrico
    Dell'Agli, Mario
    Piazza, Stefano
    NUTRIENTS, 2024, 16 (16)
12345