Anticancer properties of sulforaphane: current insights at the molecular level

被引：18

作者：

Asif Ali, Muhammad ^{[1
]}

Khan, Noohela ^{[2
]}

Kaleem, Nabeeha ^{[1
]}

Ahmad, Waqas ^{[1
]}

Alharethi, Salem Hussain ^{[3
]}

Alharbi, Bandar ^{[4
]}

Alhassan, Hassan H. ^{[5
]}

Al-Enazi, Maher M. ^{[6
]}

Razis, Ahmad Faizal Abdull ^{[7
,8
]}

Modu, Babagana ^{[8
,9
]}

Calina, Daniela ^{[10
]}

Sharifi-Rad, Javad ^{[11
]}

机构：

[1] Univ Vet & Anim Sci, Dept Food Sci & Human Nutr, Lahore, Pakistan

[2] Rashid Latif Med Coll, Dept Nutr Sci, Lahore, Pakistan

[3] Najran Univ, Coll Arts & Sci, Dept Biol Sci, Najran, Saudi Arabia

[4] Univ Hail, Coll Appl Med Sci, Dept Med Lab Sci, Hail, Saudi Arabia

[5] Jouf Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Sakaka, Saudi Arabia

[6] Prince Sattam Bin Abdulaziz Univ, Coll Appl Med Sci Al Kharj, Dept Med Lab Sci, Al Kharj, Saudi Arabia

[7] Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Sci, Serdang, Selangor, Malaysia

[8] Univ Putra Malaysia, Inst Biosci, Nat Med & Prod Res Lab, Serdang, Selangor, Malaysia

[9] Univ Maiduguri, Fac Sci, Dept Biochem, Maiduguri, Borno, Nigeria

[10] Univ Med & Pharm Craiova, Dept Clin Pharm, Craiova, Romania

[11] Univ Azuay, Fac Med, Cuenca, Ecuador

来源：

FRONTIERS IN ONCOLOGY | 2023年 / 13卷

关键词：

sulforaphane; isothiocyanate; anticancer mechanisms; cytotoxicity; apoptosis; HISTONE DEACETYLASE ACTIVITY; PHASE-II; IN-VITRO; CHEMOPREVENTIVE ACTIVITY; CANCER; PROSTATE; BROCCOLI; MEN; TARGET; CELLS;

D O I：

10.3389/fonc.2023.1168321

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli as they contain 1,153 mg/100 g. SFN is a secondary metabolite that is produced as a result of the hydrolysis of glucoraphanin (a glucosinolate) by the enzyme myrosinase. This review paper aims to summarize and understand the mechanisms behind the anticancer potential of sulforaphane. The data was collected by searching PubMed/MedLine, Scopus, Web of Science, and Google Scholar. This paper concludes that sulforaphane provides cancer protection through the alteration of various epigenetic and non-epigenetic pathways. It is a potent anticancer phytochemical that is safe to consume with minimal side effects. However, there is still a need for further research regarding SFN and the development of a standard dose.

引用

页数：9

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