Dietary quercetin protects Cherax quadricarinatus against white spot syndrome virus infection

被引：5

作者：

Gong, Jing ^{[1
]}

Zhou, Xiujuan ^{[1
]}

Pan, Xiaoyi ^{[2
]}

Zhu, Fei ^{[1
]}

机构：

[1] Zhejiang Agr & Forestry Univ, Coll Anim Sci & Technol, Coll Vet Med, Key Lab Appl Technol Green Ecohlth Anim Husb Zheji, Hangzhou 311300, Peoples R China

[2] Zhejiang Inst Freshwater Fisheries, Key Lab Hlth Freshwater Aquaculture Minist Agr & R, Key Lab Fish Hlth & Nutr Zhejiang Prov, Huzhou 313001, Peoples R China

来源：

JOURNAL OF INVERTEBRATE PATHOLOGY | 2023年 / 198卷

关键词：

Quercetin; WSSV; Cherax quadricarinatus; Innate immunity; CRAYFISH; SYSTEM;

D O I：

10.1016/j.jip.2023.107931

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

Quercetin is a plant flavonoid with a molecular formula C15H10O7. It has antioxidant, anti-inflammatory, antibacterial, and anti-apoptotic effects in animals. We used red claw crayfish (Cherax quadricarinatus) infected with white spot syndrome virus (WSSV) to investigate quercetin's effects on innate immunity of crustaceans. Quercetin supplementation significantly reduced the mortality of crayfish caused by WSSV infection and the number of VP28 copies in WSSV-infected crayfish. Quantitative real-time PCR analysis showed that dietary quercetin supplementation increased the expression of immune-related genes, like JAK, STAT and ALF. Quercetin supplementation affected the activity of six immune-related enzymes and increased the total number of hemocytes in crayfish. It also significantly reduced the rate of hemocyte apoptosis in both WSSV-infected and uninfected crayfish. These results demonstrate the potential for commercial use of quercetin for the prevention of WSSV disease in crustaceans.

引用

页数：7

共 26 条

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