Tetanus and Diphtheria Seroprotection among Children Younger Than 15 Years in Nigeria, 2018: Who Are the Unprotected Children?

被引:13
作者
Tohme, Rania A. [1 ]
Scobie, Heather M. [1 ]
Okunromade, Oyeladun [2 ]
Olaleye, Temitope [3 ]
Shuaib, Faisal [4 ]
Jegede, Tunde [2 ]
Yahaya, Ridwan [2 ]
Nnaemeka, Ndodo [2 ]
Lawal, Bola [2 ]
Egwuenu, Abiodun [2 ]
Parameswaran, Nishanth [5 ]
Cooley, Gretchen [5 ]
An, Qian [1 ]
Coughlin, Melissa [6 ]
Okposen, Bassey B. [4 ]
Adetifa, Ifedayo [2 ]
Bolu, Omotayo [1 ]
Ihekweazu, Chikwe [2 ]
机构
[1] CDCP, Global Immunizat Div, Atlanta, GA 30329 USA
[2] Nigeria Ctr Dis Control, Abuja 900211, Nigeria
[3] FCT, Inst Human Virol, Abuja 900211, Nigeria
[4] Natl Primary Healthcare Dev Agcy, Area 11, Abuja 900247, Nigeria
[5] CDCP, Div Parasit Dis & Malaria, Atlanta, GA 30329 USA
[6] CDCP, Div Viral Dis, Atlanta, GA 30329 USA
关键词
seroprevalence; tetanus; diphtheria; Nigeria; serology; vaccine preventable diseases; IMMUNITY; DISEASE; PROTECTION; COVERAGE; VACCINE; MEASLES;
D O I
10.3390/vaccines11030663
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Serological surveys provide an objective biological measure of population immunity, and tetanus serological surveys can also assess vaccination coverage. We undertook a national assessment of immunity to tetanus and diphtheria among Nigerian children aged <15 years using stored specimens collected during the 2018 Nigeria HIV/AIDS Indicator and Impact Survey, a national cross-sectional household-based survey. We used a validated multiplex bead assay to test for tetanus and diphtheria toxoid-antibodies. In total, 31,456 specimens were tested. Overall, 70.9% and 84.3% of children aged <15 years had at least minimal seroprotection (= 0.01 IU/mL) against tetanus and diphtheria, respectively. Seroprotection was lowest in the north west and north east zones. Factors associated with increased tetanus seroprotection included living in the southern geopolitical zones, urban residence, and higher wealth quintiles (p < 0.001). Full seroprotection (= 0.1 IU/mL) was the same for tetanus (42.2%) and diphtheria (41.7%), while long-term seroprotection (= 1 IU/mL) was 15.1% for tetanus and 6.0% for diphtheria. Full- and long-term seroprotection were higher in boys compared to girls (p < 0.001). Achieving high infant vaccination coverage by targeting specific geographic areas and socio-economic groups and introducing tetanus and diphtheria booster doses in childhood and adolescence are needed to achieve lifelong protection against tetanus and diphtheria and prevent maternal and neonatal tetanus.
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页数:14
相关论文
共 42 条
[1]   Multilevel analysis of predictors of multiple indicators of childhood vaccination in Nigeria [J].
Aheto, Justice Moses K. A. ;
Pannell, Oliver T. ;
Dotse-Gborgbortsi, Winfred ;
Trimner, Mary ;
Tatem, Andrew ;
Rhoda, Dale ;
Cutts, Felicity ;
Utazi, C. Edson .
PLOS ONE, 2022, 17 (05)
[2]  
[Anonymous], 2018, Weekly Epidemiological Record, V93, P173
[3]  
[Anonymous], 2017, Wkly Epidemiol Rec, V92, P53
[4]  
[Anonymous], 2017, Wkly Epidemiol Rec, V92, P417
[5]  
[Anonymous], 2018, The immunological basis for immunization series: module 3: tetanus
[6]  
[Anonymous], 2009, Immunological Basis for Immunization Series, Module 7: Measles
[7]  
[Anonymous], 2013, Afghanistan-Progress of Provinces, Multiple Indicator Cluster Survey
[8]  
[Anonymous], DEM HLTH SURV NIG
[9]  
[Anonymous], THE GUARDIAN NIGERIA
[10]   Integrated Serologic Surveillance of Population Immunity and Disease Transmission [J].
Arnold, Benjamin F. ;
Scobie, Heather M. ;
Priest, Jeffrey W. ;
Lammie, Patrick J. .
EMERGING INFECTIOUS DISEASES, 2018, 24 (07) :1188-1194