The role of glucagon-like peptide-1 (GLP-1) in fluid and food intakes in vasopressin-deficient Brattleboro rats
被引:8
作者:
Brakey, Destiny J.
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机构:
SUNY Buffalo, Dept Biol Sci, Buffalo, NY USA
SUNY Buffalo, Dept Psychol, Buffalo, NY USASUNY Buffalo, Dept Biol Sci, Buffalo, NY USA
Brakey, Destiny J.
[1
,2
]
Schatz, Kelcie C.
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SUNY Buffalo, Dept Psychol, Buffalo, NY USASUNY Buffalo, Dept Biol Sci, Buffalo, NY USA
Schatz, Kelcie C.
[2
]
Paul, Matthew J.
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机构:
SUNY Buffalo, Dept Psychol, Buffalo, NY USASUNY Buffalo, Dept Biol Sci, Buffalo, NY USA
Paul, Matthew J.
[2
]
Daniels, Derek
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机构:
SUNY Buffalo, Dept Biol Sci, Buffalo, NY USA
SUNY Buffalo, Dept Psychol, Buffalo, NY USA
SUNY Buffalo, Ctr Ingest Behav Res, Buffalo, NY USA
Univ Buffalo SUNY, Dept Biol Sci, Buffalo, NY 14260 USASUNY Buffalo, Dept Biol Sci, Buffalo, NY USA
Daniels, Derek
[1
,2
,3
,4
]
机构:
[1] SUNY Buffalo, Dept Biol Sci, Buffalo, NY USA
[2] SUNY Buffalo, Dept Psychol, Buffalo, NY USA
[3] SUNY Buffalo, Ctr Ingest Behav Res, Buffalo, NY USA
[4] Univ Buffalo SUNY, Dept Biol Sci, Buffalo, NY 14260 USA
Eating and drinking co-occur and many of the same mechanisms that control one are involved in the control of the other, making it difficult to isolate specific mechanisms for the control of fluid intake. Glucagon-like peptide-1 (GLP-1) is a peptide that seems to be involved in the endogenous control of both ingestive behaviors, but we lack a thorough understanding of how and where GLP-1 is acting to control fluid intake. Vasopressin-deficient Brattleboro rats are a model of hereditary hypothalamic diabetes insipidus that have been used extensively for the study of vasopressin actions in behavior and physiology. Here, we propose that these rats, that eat normally but drink excessively, provide a useful model to dissociate central controls of food and fluid intakes. As an initial step toward establishing this model for these purposes, we focused on GLP-1. Similar to the effect observed after treatment with a GLP-1 receptor (GLP-1R) agonist, the intake difference between wildtype and Brattleboro rats was largely a function in the number of licking bursts, indicating differences in post-ingestive feedback (e.g., satiation). When given central injections of a GLP-1R agonist, the effect on feeding was com-parable between wildtype and Brattleboro rats, but the effect of drug on fluid intake was markedly exaggerated in Brattleboro rats. Additionally, Brattleboro rats did not respond to GLP-1R antagonism, whereas wildtype rats did. Taken together, these results suggest that Brattleboro rats exhibit a selective disruption to GLP-1 ' s control of water intake. Overall, these experiments provide foundational studies of the ingestive behavior of Brattleboro rats and demonstrate the potential to use these rats to disentangle the effects of GLP-1 on food and fluid intakes.
机构:
CALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USACALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Augustine, Vineet
;
Gokce, Sertan Kutal
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CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USACALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Gokce, Sertan Kutal
;
Lee, Sangjun
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机构:
CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USACALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Lee, Sangjun
;
Wang, Bo
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机构:
CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USACALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Wang, Bo
;
Davidson, Thomas J.
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机构:
Univ Calif San Francisco, Dept Physiol, Box 0444, San Francisco, CA USA
Univ Calif San Francisco, Kavli Inst Fundamental Neurosci, San Francisco, CA 94143 USACALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Davidson, Thomas J.
;
Reimann, Frank
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Univ Cambridge, Dept Clin Biochem, Cambridge, EnglandCALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Reimann, Frank
;
Gribble, Fiona
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机构:
Univ Cambridge, Dept Clin Biochem, Cambridge, EnglandCALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Gribble, Fiona
;
Deisseroth, Karl
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机构:
Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA
Stanford Univ, Dept Bioengn, Stanford, CA 94305 USACALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Deisseroth, Karl
;
Lois, Carlos
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机构:
CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USACALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Lois, Carlos
;
Oka, Yuki
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机构:
CALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USACALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
机构:
CALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USACALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Augustine, Vineet
;
Gokce, Sertan Kutal
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h-index: 0
机构:
CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USACALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Gokce, Sertan Kutal
;
Lee, Sangjun
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机构:
CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USACALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Lee, Sangjun
;
Wang, Bo
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机构:
CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USACALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Wang, Bo
;
Davidson, Thomas J.
论文数: 0引用数: 0
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机构:
Univ Calif San Francisco, Dept Physiol, Box 0444, San Francisco, CA USA
Univ Calif San Francisco, Kavli Inst Fundamental Neurosci, San Francisco, CA 94143 USACALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Davidson, Thomas J.
;
Reimann, Frank
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Dept Clin Biochem, Cambridge, EnglandCALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Reimann, Frank
;
Gribble, Fiona
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Dept Clin Biochem, Cambridge, EnglandCALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Gribble, Fiona
;
Deisseroth, Karl
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA
Stanford Univ, Dept Bioengn, Stanford, CA 94305 USACALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Deisseroth, Karl
;
Lois, Carlos
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USACALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
Lois, Carlos
;
Oka, Yuki
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机构:
CALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA
CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USACALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA