The role of glucagon-like peptide-1 (GLP-1) in fluid and food intakes in vasopressin-deficient Brattleboro rats

被引:8
作者
Brakey, Destiny J. [1 ,2 ]
Schatz, Kelcie C. [2 ]
Paul, Matthew J. [2 ]
Daniels, Derek [1 ,2 ,3 ,4 ]
机构
[1] SUNY Buffalo, Dept Biol Sci, Buffalo, NY USA
[2] SUNY Buffalo, Dept Psychol, Buffalo, NY USA
[3] SUNY Buffalo, Ctr Ingest Behav Res, Buffalo, NY USA
[4] Univ Buffalo SUNY, Dept Biol Sci, Buffalo, NY 14260 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
Drinking; Feeding; Thirst; Glucagon-like peptide-1; Polydipsia; BODY-WEIGHT; WATER-INTAKE; SEX-DIFFERENCES; MESSENGER-RNAS; GLUCAGON-LIKE-PEPTIDE-1; RECEPTOR; DIABETES-INSIPIDUS; ANOREXIC RESPONSE; MEAL PATTERNS; SALINE INTAKE; DRINKING;
D O I
10.1016/j.physbeh.2023.114093
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Eating and drinking co-occur and many of the same mechanisms that control one are involved in the control of the other, making it difficult to isolate specific mechanisms for the control of fluid intake. Glucagon-like peptide-1 (GLP-1) is a peptide that seems to be involved in the endogenous control of both ingestive behaviors, but we lack a thorough understanding of how and where GLP-1 is acting to control fluid intake. Vasopressin-deficient Brattleboro rats are a model of hereditary hypothalamic diabetes insipidus that have been used extensively for the study of vasopressin actions in behavior and physiology. Here, we propose that these rats, that eat normally but drink excessively, provide a useful model to dissociate central controls of food and fluid intakes. As an initial step toward establishing this model for these purposes, we focused on GLP-1. Similar to the effect observed after treatment with a GLP-1 receptor (GLP-1R) agonist, the intake difference between wildtype and Brattleboro rats was largely a function in the number of licking bursts, indicating differences in post-ingestive feedback (e.g., satiation). When given central injections of a GLP-1R agonist, the effect on feeding was com-parable between wildtype and Brattleboro rats, but the effect of drug on fluid intake was markedly exaggerated in Brattleboro rats. Additionally, Brattleboro rats did not respond to GLP-1R antagonism, whereas wildtype rats did. Taken together, these results suggest that Brattleboro rats exhibit a selective disruption to GLP-1 ' s control of water intake. Overall, these experiments provide foundational studies of the ingestive behavior of Brattleboro rats and demonstrate the potential to use these rats to disentangle the effects of GLP-1 on food and fluid intakes.
引用
收藏
页数:13
相关论文
共 75 条
[1]   Modulation of appetite by gonadal steroid hormones [J].
Asarian, Lori ;
Geary, Nori .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2006, 361 (1471) :1251-1263
[2]   Sex differences in the physiology of eating [J].
Asarian, Lori ;
Geary, Nori .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2013, 305 (11) :R1215-R1267
[3]   Hierarchical neural architecture underlying thirst regulation [J].
Augustine, Vineet ;
Gokce, Sertan Kutal ;
Lee, Sangjun ;
Wang, Bo ;
Davidson, Thomas J. ;
Reimann, Frank ;
Gribble, Fiona ;
Deisseroth, Karl ;
Lois, Carlos ;
Oka, Yuki .
NATURE, 2018, 555 (7695) :204-+
[4]   Hyperphagia and Increased Fat Accumulation in Two Models of Chronic CNS Glucagon-Like Peptide-1 Loss of Function [J].
Barrera, Jason G. ;
Jones, Kenneth R. ;
Herman, James P. ;
D'Alessio, David A. ;
Woods, Stephen C. ;
Seeley, Randy J. .
JOURNAL OF NEUROSCIENCE, 2011, 31 (10) :3904-3913
[5]   Strategies and methods for research on sex differences in brain and behavior [J].
Becker, JB ;
Arnold, AP ;
Berkley, KJ ;
Blaustein, JD ;
Eckel, LA ;
Hampson, E ;
Herman, JP ;
Marts, S ;
Sadee, W ;
Steiner, M ;
Taylor, J ;
Young, E .
ENDOCRINOLOGY, 2005, 146 (04) :1650-1673
[6]   OVARIAN INFLUENCES ON MEAL PATTERNS OF FEMALE RATS [J].
BLAUSTEIN, JD ;
WADE, GN .
PHYSIOLOGY & BEHAVIOR, 1976, 17 (02) :201-208
[7]  
BOER K, 1981, J REPROD FERTIL, V61, P273
[8]   Central and peripheral GLP-1 systems independently suppress eating [J].
Brierley, Daniel I. ;
Holt, Marie K. ;
Singh, Arashdeep ;
de Araujo, Alan ;
McDougle, Molly ;
Vergara, Macarena ;
Afaghani, Majd H. ;
Lee, Shin Jae ;
Scott, Karen ;
Maske, Calyn ;
Langhans, Wolfgang ;
Krause, Eric ;
de Kloet, Annette ;
Gribble, Fiona M. ;
Reimann, Frank ;
Rinaman, Linda ;
de Lartigue, Guillaume ;
Trapp, Stefan .
NATURE METABOLISM, 2021, 3 (02) :258-+
[9]   INGESTIVE BEHAVIORS OF THE RAT DEFICIENT IN VASOPRESSIN SYNTHESIS (BRATTLEBORO STRAIN) - EFFECT OF CHRONIC TREATMENT BY DDAVP [J].
BURLET, A ;
DESOR, D ;
MAX, JP ;
NICOLAS, JP ;
KRAFFT, B ;
BURLET, C .
PHYSIOLOGY & BEHAVIOR, 1990, 48 (06) :813-819
[10]   INDEPENDENT EFFECTS OF ESTRADIOL ON WATER AND FOOD-INTAKE [J].
CZAJA, JA ;
BUTERA, PC ;
MCCAFFREY, TA .
BEHAVIORAL NEUROSCIENCE, 1983, 97 (02) :210-220