Radiation exposure determination in a secure, cloud-based online environment

被引：0
作者：
Shirley, Ben C. [1 ]
Mucaki, Eliseos J. [2 ]
Knoll, Joan H. M. [1 ,3 ]
Rogan, Peter K. [1 ,2 ]
机构：
[1] CytoGnomix Inc, 60 N Ctr Rd, London, ON N5X 3X5, Canada
[2] Univ Western Ontario, Dept Biochem, London, ON N6A 3K7, Canada
[3] Univ Western Ontario, Dept Pathol & Lab Med, London, ON N6A 3K7, Canada
来源：
RADIATION PROTECTION DOSIMETRY | 2023年 / 199卷 / 14期
关键词：
CHROMOSOMES; ISSUES;
D O I：
10.1093/rpd/ncac266
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Rapid sample processing and interpretation of estimated exposures will be critical for triaging exposed individuals after a major radiation incident. The dicentric chromosome (DC) assay assesses absorbed radiation using metaphase cells from blood. The Automated Dicentric Chromosome Identifier and Dose Estimator System (ADCI) identifies DCs and determines radiation doses. This study aimed to broaden accessibility and speed of this system, while protecting data and software integrity. ADCI Online is a secure web-streaming platform accessible worldwide from local servers. Cloud-based systems containing data and software are separated until they are linked for radiation exposure estimation. Dose estimates are identical to ADCI on dedicated computer hardware. Image processing and selection, calibration curve generation, and dose estimation of 9 test samples completed in < 2 days. ADCI Online has the capacity to alleviate analytic bottlenecks in intermediate-to-large radiation incidents. Multiple cloned software instances configured on different cloud environments accelerated dose estimation to within clinically relevant time frames.
引用
收藏
页码：1465 / 1471
页数：7
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