Is chymase 1 a therapeutic target in cardiovascular disease?

被引：2
作者：
Ferrario, Carlos M. [1 ,5 ]
Ahmad, Sarfaraz [1 ]
Speth, Robert [2 ]
Dell'Italia, Louis J. [3 ,4 ]
机构：
[1] Wake Forest Sch Med, Dept Surg, Lab Translat Hypertens & Vasc Res, Winston Salem, NC USA
[2] Nova Southeastern Univ, Dept Pharmaceut Sci, Ft Lauderdale, FL USA
[3] Univ Alabama Birmingham UAB, Dept Med, Div Cardiovasc Dis, Birmingham, AL USA
[4] Birmingham Dept Vet Affairs Hlth Care Syst, Birmingham, AL USA
[5] Wake Forest Sch Med, Dept Surg, Atrium Hlth Wake Forest Baptist, Med Ctr Blvd, Winston Salem, NC 27157 USA
来源：
EXPERT OPINION ON THERAPEUTIC TARGETS | 2023年 / 27卷 / 08期
基金：
美国国家卫生研究院;
关键词：
Angiotensin converting enzyme; angiotensin-(1-12); chronic kidney disease; chymase; diabetes mellitus; heart failure; primary hypertension; vascular disease; ANGIOTENSIN-CONVERTING ENZYME; MAST-CELL CHYMASE; DEPENDENT MATRIX-METALLOPROTEINASE-9 ACTIVATION; ABDOMINAL AORTIC-ANEURYSM; PREVENTS CARDIAC FIBROSIS; II FORMATION; MYOCARDIAL-INFARCTION; RECEPTOR BLOCKERS; BLOOD-PRESSURE; OXIDATIVE STRESS;
D O I：
10.1080/14728222.2023.2247561
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
IntroductionNon-angiotensin converting enzyme mechanisms of angiotensin II production remain underappreciated in part due to the success of current therapies to ameliorate the impact of primary hypertension and atherosclerotic diseases of the heart and the blood vessels. This review scrutinize the current literature to highlight chymase role as a critical participant in the pathogenesis of cardiovascular disease and heart failure.Areas coveredWe review the contemporaneous understanding of circulating and tissue biotransformation mechanisms of the angiotensins focusing on the role of chymase as an alternate tissue generating pathway for angiotensin II pathological mechanisms of action.Expert opinionWhile robust literature documents the singularity of chymase as an angiotensin II-forming enzyme, particularly when angiotensin converting enzyme is inhibited, this knowledge has not been fully recognized to clinical medicine. This review discusses the limitations of clinical trials' that explored the benefits of chymase inhibition in accounting for the failure to duplicate in humans what has been demonstrated in experimental animals.
引用
收藏
页码：645 / 656
页数：12
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