Vascular Health of Females with History of Assisted Reproductive Technology

被引：1

作者：

Li, Pengzhu ^{[1
]}

Langer, Magdalena ^{[1
]}

Vilsmaier, Theresa ^{[2
]}

Kramer, Marie ^{[1
]}

Sciuk, Franziska ^{[1
]}

Kolbinger, Brenda ^{[1
,2
]}

Jakob, Andre ^{[1
]}

Rogenhofer, Nina ^{[2
]}

Dalla-Pozza, Robert ^{[1
]}

Thaler, Christian ^{[2
]}

Haas, Nikolaus Alexander ^{[1
]}

Oberhoffer, Felix Sebastian ^{[1
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Univ Hosp, Div Pediat Cardiol & Intens Care, D-81377 Munich, Germany

[2] Univ Munich, Dept Gynecol & Obstet, Div Gynecol Endocrinol & Reprod Med, LMU Munich, Munich D-81377, Germany

来源：

JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE | 2024年 / 11卷 / 02期

关键词：

infertility; assisted reproductive technologies; females; vascular health; 2-DIMENSIONAL SPECKLE TRACKING; CARDIOVASCULAR RISK; ARTERIAL STIFFNESS; WORKING GROUP; LIPOPROTEIN(A); CHILDREN; INFERTILITY; ASSOCIATION; DYSFUNCTION; WOMEN;

D O I：

10.3390/jcdd11020066

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The use of assisted reproductive technologies (ART) for the treatment of infertility is gaining popularity. Limited data on the overall vascular health of females with history of ART are available. This pilot study aimed to investigate the overall vascular health of females with history of ART compared to individuals who conceived spontaneously. The assessment of overall vascular health included the measurement of brachial blood pressure, central blood pressure, and pulse wave velocity, as well as the evaluation of the arterial stiffness and carotid intima-media thickness (cIMT) of the common carotid arteries. Conventional blood lipids including lipoprotein a (Lp(a)) were also determined. In total, 45 females with history of ART and 52 females who conceived spontaneously were included (mean age: 47.72 +/- 5.96 years vs. 46.84 +/- 7.43 years, p = 0.525). An initial comparison revealed a significantly higher prevalence of elevated Lp(a) in ART females (p = 0.011). However, after multiple comparison correction, the significant result disappeared (p = 0.132). Within the cohort of ART females, no significantly higher cardiovascular risk was detected regarding vascular function. The potentially higher prevalence of elevated Lp(a) in ART females must be further investigated in future studies, as it might contribute to the impaired reproductive process in this cohort.

引用

页数：12

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