Kinetics of neutrophil extracellular traps and cytokines in oral mucositis and Candida infection

被引：1

作者：

Almeida de Arruda, Jose Alcides ^{[1
]}

Oliveira, Sicilia Rezende ^{[1
]}

Heimlich, Fernanda Vieira ^{[1
]}

de Amorim-Santos, Barbara Maria ^{[2
]}

Schneider, Ayda Henriques ^{[3
]}

Velasco Ponde de Sena, Ana Carolina ^{[4
]}

de Sa Rodrigues, Karla Emilia ^{[5
]}

Macari, Soraia ^{[6
]}

Souza, Daniele Gloria ^{[2
]}

Travassos, Denise Vieira ^{[7
,8
]}

Abreu, Lucas Guimares ^{[9
]}

Silva, Tarcilia Aparecida ^{[1
,7
]}

Mesquita, Ricardo Alves ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg Pathol & Clin Dent, Av Pres Antonio Carlos,6627,Room 3202, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Inst Biol Sci, Dept Microbiol, Belo Horizonte, MG, Brazil

[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ribeirao Preto, Brazil

[4] Univ Fed Bahia, Sch Dent, Postgrad Program Dent & Hlth, Salvador, BA, Brazil

[5] Barretos Canc Hosp Barretos Sao Paulo, Childrens Canc Hosp, Dept Pediat Oncol, Barretos, SP, Brazil

[6] Univ Fed Minas Gerais, Sch Dent, Dept Restorat Dent, Belo Horizonte, MG, Brazil

[7] Univ Fed Minas Gerais, Hosp Clin, Multiprofess Integrated Residency Hlth, Belo Horizonte, MG, Brazil

[8] Univ Fed Minas Gerais, Sch Dent, Dept Social & Prevent Dent, Belo Horizonte, MG, Brazil

[9] Univ Fed Minas Gerais, Sch Dent, Dept Child & Adolescent Oral Hlth, Belo Horizonte, MG, Brazil

来源：

ORAL DISEASES | 2024年 / 30卷 / 07期

关键词：

Candida; chemotherapy; cytokines; neutrophil extracellular traps; oncology; oral mucositis; PRO-INFLAMMATORY CYTOKINES; CANCER-PATIENTS; PATHOBIOLOGY; BIOMARKERS;

D O I：

10.1111/odi.14857

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

ObjectiveThis study investigated the concentrations of neutrophil extracellular traps (NET) and salivary cytokines (IL-1 beta, IL-6, IL-8/CXCL8, TNF, and TGF-beta 1) in patients undergoing chemotherapy and their associations with oral mucositis (OM) and Candida infection. Materials and MethodsThis prospective longitudinal study performed at a Brazilian service included 60 adults diagnosed with hematolymphoid diseases. Saliva samples were collected on days D0, D3, D10, and D15. Cytokines were analyzed by ELISA and NET formation by identification of the myeloperoxidase-DNA complex. Oral Candida spp. was cultured. ResultsOM occurred in 43.3% of patients and oral candidiasis in 20%. However, 66% of individuals had positive cultures for C. albicans. Higher concentrations of IL-6, IL-8/CXCL8, and TNF and lower concentrations of TGF-beta 1 were observed in patients with OM. C. albicans infection contributed to the increase in IL-8/CXCL8, TGF-beta 1, and TNF. Individuals with OM or with oral candidiasis had significant reductions in NET formation. In contrast, individuals with C. albicans and with concomitant C. albicans and OM exhibited higher NET formation. ConclusionThe kinetics of cytokine levels and NET formation in chemotherapy-induced OM appears to be altered by Candida infection, even in the absence of clinical signs of oral candidiasis.

引用

页码：4751 / 4761

页数：11

共 47 条

[1] Neutrophil swarming delays the growth of clusters of pathogenic fungi [J].

Alex, Hopke ;

Scherer, Allison ;

Kreuzburg, Samantha ;

Abers, Michael S. ;

Zerbe, Christa S. ;

Dinauer, Mary C. ;

Mansour, Michael K. ;

Irimia, Daniel .

NATURE COMMUNICATIONS, 2020, 11 (01)

[2] Burden of Oral Mucositis: A Systematic Review and Implications for Future Research [J].

Berger, Karin ;

Schopohl, Dorothee ;

Bollig, Antonia ;

Strobach, Dorothea ;

Rieger, Christina ;

Rublee, Dale ;

Ostermann, Helmut .

ONCOLOGY RESEARCH AND TREATMENT, 2018, 41 (06) :399-405

[3] Chemotherapy Induces Oral Mucositis in Mice Without Additional Noxious Stimuli [J].

Bertolini, M. ;

Sobue, T. ;

Thompson, A. ;

Dongari-Bagtzoglou, A. .

TRANSLATIONAL ONCOLOGY, 2017, 10 (04) :612-620

[4] The role of Smad7 in oral mucositis [J].

Bian, Li ;

Han, Gangwen ;

Zhao, Carolyn W. ;

Garl, Pamela J. ;

Wang, Xiao-Jing .

PROTEIN & CELL, 2015, 6 (03) :160-169

[5] Neutrophil extracellular traps kill bacteria [J].

Brinkmann, V ;

Reichard, U ;

Goosmann, C ;

Fauler, B ;

Uhlemann, Y ;

Weiss, DS ;

Weinrauch, Y ;

Zychlinsky, A .

SCIENCE, 2004, 303 (5663) :1532-1535

[6] Efficacy of chlorhexidine for the prevention and treatment of oral mucositis in cancer patients: a systematic review with meta-analyses [J].

Cardona, Alvin ;

Balouch, Amir ;

Abdul, Moiz Mohammed ;

Sedghizadeh, Parish P. ;

Enciso, Reyes .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2017, 46 (09) :680-688

[7] Oral Mucositis: An Update on Innate Immunity and New Interventional Targets [J].

Chen, C. ;

Zhang, Q. ;

Yu, W. ;

Chang, B. ;

Le, A. D. .

JOURNAL OF DENTAL RESEARCH, 2020, 99 (10) :1122-1130

[8] Correlation between Oxidative Stress and Transforming Growth Factor-Beta in Cancers [J].

Chung, Jinwook ;

Huda, Md Nazmul ;

Shin, Yoonhwa ;

Han, Sunhee ;

Akter, Salima ;

Kang, Insug ;

Ha, Joohun ;

Choe, Wonchae ;

Choi, Tae Gyu ;

Kim, Sung Soo .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (24)

[9] Determination of cytokine protein levels in oral secretions in patients undergoing radiotherapy for head and neck malignancies [J].

Citrin, Deborah E. ;

Hitchcock, Ying J. ;

Chung, Eun Joo ;

Frandsen, Jonathan ;

Urick, Mary Ellen ;

Shield, William ;

Gaffney, David .

RADIATION ONCOLOGY, 2012, 7

[10] Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis [J].

Costa Normando, Ana Gabriela ;

Rocha, Camila Lopes ;

de Toledo, Isabela Porto ;

de Souza Figueiredo, Paulo Tadeu ;

Diniz dos Reis, Paula Elaine ;

Canto, Graziela De Luca ;

Silva Guerra, Eliete Neves .

SUPPORTIVE CARE IN CANCER, 2017, 25 (09) :2969-2988

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