Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX

被引：42

作者：

Kanis, J. A. ^{[1
,2
]}

Johansson, H. ^{[1
,3
]}

McCloskey, E., V ^{[2
,4
]}

Liu, E. ^{[1
]}

Akesson, K. E. ^{[5
,6
]}

Anderson, F. A. ^{[7
]}

Azagra, R. ^{[8
,9
,10
]}

Bager, C. L. ^{[11
]}

Beaudart, C. ^{[12
,13
]}

Bischoff-Ferrari, H. A. ^{[14
,15
,16
,17
]}

Biver, E. ^{[18
,19
]}

Bruyere, O. ^{[12
]}

Cauley, J. A. ^{[20
]}

Center, J. R. ^{[21
,22
,23
]}

Chapurlat, R. ^{[24
]}

Christiansen, C. ^{[11
]}

Cooper, C. ^{[25
,26
,27
,28
]}

Crandall, C. J. ^{[29
]}

Cummings, S. R. ^{[30
]}

da Silva, J. A. P. ^{[31
,32
]}

Dawson-Hughes, B. ^{[33
]}

Diez-Perez, A. ^{[34
,35
]}

Dufour, A. B. ^{[36
,37
]}

Eisman, J. A. ^{[21
,22
,23
]}

Elders, P. J. M. ^{[38
]}

Ferrari, S. ^{[18
,19
]}

Fujita, Y. ^{[39
]}

Fujiwara, S. ^{[40
]}

Glueer, C. -C. ^{[41
]}

Goldshtein, I. ^{[42
,43
]}

Goltzman, D. ^{[44
]}

Gudnason, V. ^{[45
,46
,47
,48
]}

Hall, J. ^{[49
]}

Hans, D. ^{[50
,51
]}

Hoff, M. ^{[52
,53
]}

Hollick, R. J. ^{[54
]}

Huisman, M. ^{[55
,56
]}

Iki, M. ^{[57
]}

Ish-Shalom, S. ^{[58
]}

Jones, G. ^{[59
]}

Karlsson, M. K.

Khosla, S. ^{[60
,61
]}

Kiel, D. P. ^{[36
,37
]}

Koh, W. -P. ^{[62
,63
]}

Koromani, F. ^{[64
,65
]}

Kotowicz, M. A. ^{[66
,67
,68
]}

Kroger, H. ^{[69
,70
]}

Kwok, T. ^{[71
,72
]}

Lamy, O. ^{[73
,74
]}

Langhammer, A. ^{[75
]}

机构：

[1] Australian Catholic Univ, Mary McKillop Inst Hlth Res, Melbourne, Vic, Australia

[2] Univ Sheffield, Ctr Metab Bone Dis, Sheffield, S Yorkshire, England

[3] Univ Gothenburg, Inst Med, Sahlgrenska Osteoporosis Ctr, Gothenburg, Sweden

[4] Univ Sheffield, MRC Versus Arthrit Ctr Integrated Res Musculoskel, Mellanby Ctr Musculoskeletal Res, Sheffield, S Yorkshire, England

[5] Lund Univ, Dept Clin Sci, Clin & Mol Osteoporosis Res Unit, Lund, Sweden

[6] Skane Univ Hosp, Dept Orthoped, Malmo, Sweden

[7] Univ Massachusetts, Med Sch, GLOW Coordinating Ctr, Ctr Outcomes Res, Worcester, MA USA

[8] Autonomous Univ Barcelona, Dept Med, Barcelona, Spain

[9] Catalan Inst Hlth, Hlth Ctr Badia Valles, Barcelona, Spain

[10] PRECIOSA Fdn Invest, Barcelona, Spain

[11] Nord Biosci AS, Herlev, Denmark

[12] Univ Liege, Div Publ Hlth Epidemiol & Hlth Econ, WHO Collaborating Ctr Publ Hlth Aspects Musculosk, Liege, Belgium

[13] Univ Maastricht, Dept Hlth Serv Res, Maastricht, Netherlands

[14] Univ Hosp Zurich, Dept Aging Med & Aging Res, Zurich, Switzerland

[15] Univ Zurich, Zurich, Switzerland

[16] Univ Zurich, Ctr Aging & Mobil, Zurich, Switzerland

[17] City Hosp, Zurich, Switzerland

[18] Geneva Univ Hosp, Dept Med, Div Bone Dis, Geneva, Switzerland

[19] Univ Geneva, Fac Med, Geneva, Switzerland

[20] Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA

[21] Garvan Inst Med Res, Skeletal Dis Program, Sydney, NSW, Australia

[22] Univ New South Wales Sydney, Sch Med & Hlth, St Vincents Clin Sch, Sydney, NSW, Australia

[23] Univ Notre Dame Australia, Sch Med Sydney, Sydney, NSW, Australia

[24] Univ Claude Bernard Lyon1, INSERM, Hop Edouard Herriot, UMR 1033, Lyon, France

[25] Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, Hants, England

[26] Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England

[27] Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England

[28] Univ Oxford, NIHR Oxford Biomed Res Unit, Oxford, England

[29] Univ Calif Los Angeles, David Geffen Sch Med, Div Gen Internal Med & Hlth Serv Res, Los Angeles, CA 90095 USA

[30] Calif Pacific Med Ctr Res Inst, San Francisco Coordinating Ctr, San Francisco, CA USA

[31] Univ Coimbra, Coimbra Inst Clin & Biomed Res, Fac Med, Coimbra, Portugal

[32] Ctr Hosp & Univ Coimbra, Dept Rheumatol, Coimbra, Portugal

[33] Tufts Univ, Jean Mayer US Dept Agr Human Nutr Res Ctr Aging, Bone Metab Lab, Boston, MA 02111 USA

[34] Autonomous Univ Barcelona, Hosp del Mar, Dept Internal Med, Barcelona, Spain

[35] Autonomous Univ Barcelona, CIBERFES, Barcelona, Spain

[36] Hebrew Senior Life, Marcus Inst Aging Res, Boston, MA USA

[37] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA

[38] Harvard Med Sch, Boston, MA 02115 USA

[39] Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Locat AMC, Petra JM Elders Dept Gen Practice, Amsterdam, Netherlands

[40] Kindai Univ, Ctr Med Educ & Clin Training, Fac Med, Osaka, Japan

[41] Yasuda Womens Univ, Dept Pharm, Hiroshima, Japan

[42] Univ Kiel, Univ Med Ctr Schleswig Holstein Kiel, Sect Biomed Imaging, Mol Imaging North Competence Ctr,Dept Radiol & Ne, Kiel, Germany

[43] Maccabi Healthcare Serv, Maccabitech Inst Res & Innovat, Tel Aviv, Israel

[44] Tel Aviv Univ, Sch Publ Hlth, Dept Epidemiol & Prevent Med, Sackler Fac Med, Tel Aviv, Israel

[45] McGill Univ, Dept Med, Montreal, PQ, Canada

[46] McGill Univ, Hlth Ctr, Montreal, PQ, Canada

[47] Iceland Heart Assoc, Kopavogur, Iceland

[48] Univ Iceland, Reykjavik, Iceland

[49] Univ Edinburgh, MRC Ctr Reprod Hlth, Edinburgh, Midlothian, Scotland

[50] Lausanne Univ Hosp CHUV, Bone & Joint Dept, Interdisciplinary Ctr Bone Dis, Lausanne, Switzerland

来源：

OSTEOPOROSIS INTERNATIONAL | 2023年 / 34卷 / 12期

基金：

美国国家卫生研究院;

关键词：

Hip fracture; Major osteoporotic fracture; Meta-analysis; Osteoporotic fracture; Prior fracture; TRABECULAR BONE SCORE; VERTEBRAL FRACTURE; HIP FRACTURE; OSTEOPOROSIS; PREDICTION; SEVERITY; TIME;

D O I：

10.1007/s00198-023-06870-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A large international meta-analysis using primary data from 64 cohorts has quantified the increased risk of fracture associated with a previous history of fracture for future use in FRAX.IntroductionThe aim of this study was to quantify the fracture risk associated with a prior fracture on an international basis and to explore the relationship of this risk with age, sex, time since baseline and bone mineral density (BMD).MethodsWe studied 665,971 men and 1,438,535 women from 64 cohorts in 32 countries followed for a total of 19.5 million person-years. The effect of a prior history of fracture on the risk of any clinical fracture, any osteoporotic fracture, major osteoporotic fracture, and hip fracture alone was examined using an extended Poisson model in each cohort. Covariates examined were age, sex, BMD, and duration of follow-up. The results of the different studies were merged by using the weighted & beta;-coefficients.ResultsA previous fracture history, compared with individuals without a prior fracture, was associated with a significantly increased risk of any clinical fracture (hazard ratio, HR = 1.88; 95% CI = 1.72-2.07). The risk ratio was similar for the outcome of osteoporotic fracture (HR = 1.87; 95% CI = 1.69-2.07), major osteoporotic fracture (HR = 1.83; 95% CI = 1.63-2.06), or for hip fracture (HR = 1.82; 95% CI = 1.62-2.06). There was no significant difference in risk ratio between men and women. Subsequent fracture risk was marginally downward adjusted when account was taken of BMD. Low BMD explained a minority of the risk for any clinical fracture (14%), osteoporotic fracture (17%), and for hip fracture (33%). The risk ratio for all fracture outcomes related to prior fracture decreased significantly with adjustment for age and time since baseline examination.ConclusionA previous history of fracture confers an increased risk of fracture of substantial importance beyond that explained by BMD. The effect is similar in men and women. Its quantitation on an international basis permits the more accurate use of this risk factor in case finding strategies.

引用

页码：2027 / 2045

页数：19

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