Two New Amides from Physochlainae Radix

被引：4

作者：

Tan, Jin-Yan ^{[1
]}

Li, Jian-Li ^{[1
]}

Li, Pei ^{[1
]}

Zhang, Lu ^{[2
]}

Cheng, Yan-Gang ^{[1
]}

Wang, Yan ^{[1
]}

Ma, Xiao-Nan ^{[3
]}

Hao, Xu-Liang ^{[2
]}

Wang, Ying-Li ^{[1
]}

机构：

[1] Shanxi Univ Chinese Med, Shanxi Modern Chinese Med Engn Lab, Jinzhong 030619, Peoples R China

[2] Shanxi Univ Chinese Med, Affiliated Hosp, Taiyuan 030024, Peoples R China

[3] Shanxi Med Univ, Sch Pharm, Jinzhong 030600, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2023年 / 20卷 / 09期

关键词：

Solanaceae; Physochlaina infundibularis; amides; anti-inflammatory activities; chemical composition;

D O I：

10.1002/cbdv.202300556

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this article, two undescribed amides (1-2) with an unusual (2-formyl-5-hydroxymethyl)pyrroyl-butylamine moiety were obtained from the Physochlainae Radix. Comprehensive spectroscopic studies, including NMR and HR-ESI-MS, coupling with spectroscopic data comparisons were used to determine structures. Anti-inflammatory assay results showed that new amides possessed significant inhibitory activities of the NO production of LPS-induced RAW 264.7 cells, with IC50 values of 17.52 & PLUSMN;1.68 & mu;M and 20.37 & PLUSMN;2.42 & mu;M, respectively.

引用

页数：4

共 10 条

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