Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike

被引：14
作者：
Wrobel, Antoni G. [1 ]
机构：
[1] Francis Crick Inst, Struct Biol Dis Proc Lab, London, England
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 2023年 / 81卷
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
BAT CORONAVIRUS; CRYO-EM; DYNAMICS; PROTEIN; VIRUS; ENTRY;
D O I：
10.1016/j.sbi.2023.102619
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
host cells by facilitating virus attachment and membrane fusion. ACE2 is the main receptor of SARS-CoV-2 and its interaction with spike has shaped the virus' emergence from an animal reservoir and subsequent evolution in the human host. Many structural studies on the spike:ACE2 interaction have provided insights into mechanisms driving viral evolution during the on-going pandemic. This review describes the molecular basis of spike binding to ACE2, outlines mechanisms that have optimised this interaction during viral evolution, and suggests directions for future research.
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页数：10
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