Synthesis, characterization, antibacterial and antifungal evaluation of novel cyclohexanone benzoylhydrazones

被引：6

作者：

Cihan-Ustundag, Gokce ^{[1
]}

Mataraci-Kara, Emel ^{[2
]}

Capan, Gultaze ^{[1
]}

机构：

[1] Istanbul Univ, Fac Pharm, Dept Pharmaceut Chem, Istanbul, Turkey

[2] Istanbul Univ, Fac Pharm, Dept Pharmaceut Microbiol, Istanbul, Turkey

来源：

ISTANBUL JOURNAL OF PHARMACY | 2019年 / 49卷 / 03期

关键词：

Hydrazone; cyclohexanone; antibacterial activity; antifungal activity; ANTIMICROBIAL ACTIVITY; HYDRAZONES; HYDRAZIDES; QSAR; BEARING;

D O I：

10.26650/IstanbulJPharm.2019.19022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A novel series of benzoyl hydrazones (2a-j) were synthesized and evaluated, in vitro, for antimicrobial activity against selected bacteria and fungi. The structures of the compounds were established by IR, H-1-NMR, C-13-NMR (APT), electrospray ionization mass spectrometry (ESI-MS) and micro analysis (C, H, N). All of the tested compounds, except for compound 2h, displayed weak antibacterial properties against Staphylococcus epidermidis ATCC 12228 and Staphylococcus aureus ATCC 29213. Compounds 2a, 2b, 2e, 2f and 2i further exhibited marginal antifungal activity against Candida parapsilosis.

引用

页码：142 / 147

页数：6

共 25 条

[1] Synthesis and antifungal activity of substituted salicylaldehyde hydrazones, hydrazides and sulfohydrazides [J].

Backes, Gregory L. ;

Neumann, Donna M. ;

Jursic, Branko S. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (17) :4629-4636

[2]

Clinical and Laboratory Standards Institute, 2006, M7-A7, V7th ed.

[3]

Clinical and Laboratory Standards Institute, 1997, M27A2 CLSI

[4] Synthesis, crystal structure, optical properties and antibacterial evaluation of novel imidazo[1, 5-a]pyridine derivatives bearing a hydrazone moiety [J].

Ge, Yan Qing ;

Li, Fu Rong ;

Zhang, Yu Juan ;

Bi, Yu Shui ;

Cao, Xiao Qun ;

Duan, Gui Yun ;

Wang, Jian Wu ;

Liu, Zhen Liang .

LUMINESCENCE, 2014, 29 (03) :293-300

[5] Investigation of Antimicrobial Activities of Indole-3-Aldehyde Hydrazide/Hydrazone Derivatives [J].

Gurkok, Gokce ;

Altanlar, Nurten ;

Suzen, Sibel .

CHEMOTHERAPY, 2009, 55 (01) :15-19

[6]

Kaplancikli ZA, 2014, LETT DRUG DES DISCOV, V11, P76

[7] Benzylidene/2-chlorobenzylidene hydrazides: Synthesis, antimicrobial activity, QSAR studies and antiviral evaluation [J].

Kumar, Davinder ;

Judge, Vikramjeet ;

Narang, Rakesh ;

Sangwan, Sonia ;

De Clercq, Erik ;

Balzarini, Jan ;

Narasimhan, Balasubramanian .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (07) :2806-2816

[8] Achieving global targets for antimicrobial resistance [J].

Laxminarayan, Ramanan ;

Sridhar, Devi ;

Blaser, Martin ;

Wang, Minggui ;

Woolhouse, Mark .

SCIENCE, 2016, 353 (6302) :874-875

[9] Past, Present, and Future of Antibacterial Economics: Increasing Bacterial Resistance, Limited Antibiotic Pipeline, and Societal Implications [J].

Luepke, Katherine H. ;

Suda, Katie J. ;

Boucher, Helen ;

Russo, Rene L. ;

Bonney, Michael W. ;

Hunt, Timothy D. ;

Mohr, John F., III .

PHARMACOTHERAPY, 2017, 37 (01) :71-84

[10]

Moldovan C, 2011, FARMACIA, V59, P659

← 1 2 3 →