Associations of alanine aminotransferase/aspartate aminotransferase with insulin resistance and β-cell function in women

被引：15

作者：

Minato-Inokawa, Satomi ^{[1
,2
,3
]}

Tsuboi-Kaji, Ayaka ^{[1
,4
]}

Honda, Mari ^{[5
,6
]}

Takeuchi, Mika ^{[1
]}

Kitaoka, Kaori ^{[1
,7
]}

Kurata, Miki ^{[1
,8
]}

Wu, Bin ^{[5
,9
]}

Kazumi, Tsutomu ^{[1
,5
,10
]}

Fukuo, Keisuke ^{[1
,5
,8
]}

机构：

[1] Mukogawa Womens Univ, Res Inst Nutr Sci, 6-46,Ikebiraki Cho, Nishinomiya, Hyogo 6638558, Japan

[2] Ehime Univ, Grad Sch Agr, Dept Biosci, Lab Community Hlth & Nutr, Matsuyama, Ehime, Japan

[3] Kyoto Univ, Grad Sch Med & Publ Hlth, Dept Pharmacoepidemiol, Kyoto, Japan

[4] Osaka City Juso Hosp, Dept Nutr, Osaka, Japan

[5] Mukogawa Womens Univ, Open Res Ctr Studying Lifestyle Related Dis, Nishinomiya, Hyogo, Japan

[6] Kobe Womens Univ, Fac Hlth & Welf, Dept Hlth Sports & Nutr, Kobe, Hyogo, Japan

[7] Shiga Univ Med Sci, Noncommunicable Dis NCD Epidemiol Res Ctr, Dept Adv Epidemiol, Otsu, Shiga, Japan

[8] Mukogawa Womens Univ, Dept Food Sci & Nutr, Nishinomiya, Hyogo, Japan

[9] Kunming Med Univ, Affiliated Hosp 1, Dept Endocrinol, Kunming, Yunnan, Peoples R China

[10] Kohan Kakogawa Hosp, Dept Med, Kakogawa, Hyogo, Japan

来源：

SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期

基金：

日本学术振兴会;

关键词：

FATTY LIVER-DISEASE; RATIO; SENSITIVITY; GLUCOSE; INDEX; RISK; STEATOSIS; ENZYMES; PROTEIN;

D O I：

10.1038/s41598-023-35001-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We tested whether alanine aminotransferase/aspartate aminotransferase (ALT/AST), a marker of hepatosteatosis, associates with insulin resistance, beta-cell function and postglucose glycemia. We studied 311 young and 148 middle-aged Japanese women, whose BMI averaged < 23.0 kg/m(2). Insulinogenic index and Matsuda index were evaluated in 110 young and 65 middle-aged women. In two groups of women, ALT/AST was associated positively with homeostasis model assessment insulin resistance (HOMA-IR) and inversely with Matsuda index. In middle-aged women only, the ratio was also associated positively with fasting and postload glycemia and HbA1c. The ratio showed negative association with disposition index (a product of insulinogenic index and Matsuda index). On multivariate linear regression analysis, HOMA-IR emerged as a single determinant of ALT/AST in young and middle-aged women (standardized beta: 0.209, p = 0.003 and 0.372, p = 0.002, respectively). ALT/AST was associated with insulin resistance and beta-cell function even in non-obese Japanese women, suggesting a pathophysiologic basis in its prediction of diabetic risk.

引用

页数：7