Female infertility in the era of obesity: The clash of two pandemics or inevitable consequence?

被引：13

作者：

Medenica, Sanja ^{[1
]}

Spoltore, Maria Elena ^{[2
]}

Ormazabal, Paulina ^{[3
,4
]}

Marina, Ljiljana V. ^{[5
]}

Sojat, Antoan Stefan ^{[6
]}

Faggiano, Antongiulio ^{[7
]}

Gnessi, Lucio ^{[2
]}

Mazzilli, Rossella ^{[7
]}

Watanabe, Mikiko ^{[2
]}

机构：

[1] Univ Montenegro, Fac Med, Clin Ctr Montenegro, Dept Internal Med,Endocrinol Sect, Podgorica, Montenegro

[2] Sapienza Univ Rome, Dept Expt Med, Sect Med Pathophysiol Food Sci & Endocrinol, Rome, Italy

[3] Univ OHiggins, Inst Hlth Sci, Rancagua, Chile

[4] Univ Chile, Inst Nutr & Food Technol INTA, Lab Obes & Metab Geriatr & Adults OMEGA, Santiago, Chile

[5] Univ Belgrade, Univ Clin Ctr Serbia, Dept Obes Metab & Reprod Disorders, Fac Med,Clin Endocrinol Diabet & Metab Dis, Belgrade, Serbia

[6] Univ Clin Ctr Serbia, Dept Obes Metab & Reprod Disorders, Clin Endocrinol Diabet & Metab Dis, Belgrade, Serbia

[7] Sapienza Univ Rome, AOU StAndrea, Dept Clin & Mol Med, Via Grottarossa 1035, I-1039 Rome, Italy

来源：

CLINICAL ENDOCRINOLOGY | 2023年 / 98卷 / 02期

关键词：

assisted reproductive technology; body mass index; in vitro fertilization; miscarriage; overweight; polycystic ovary syndrome; pregnancy; POLYCYSTIC-OVARY-SYNDROME; IN-VITRO FERTILIZATION; CUMULATIVE LIVE-BIRTH; BODY-MASS INDEX; CLOMIPHENE CITRATE; INSULIN-RESISTANCE; SYNDROME PCOS; WEIGHT-LOSS; WOMEN; IVF;

D O I：

10.1111/cen.14785

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is an epidemic that has led to a rise in the incidence of many comorbidities: among others, reduced fertility is often under-evaluated in clinical practice. The mechanisms underlying the link between reduced fertility and obesity are numerous, with insulin resistance, hyperglycaemia and the frequent coexistence of polycystic ovary syndrome being the most acknowledged. However, several other factors concur, such as gut microbiome alterations, low-grade chronic inflammation and oxidative stress. Not only do women with obesity take longer to conceive, but in vitro fertilization (IVF) is also less likely to succeed. We herein provide an updated state-of-the-art regarding the molecular bases of what we could define as dysmetabolic infertility, focusing on the clinical aspects, as well as possible treatment.

引用

页码：141 / 152

页数：12

共 141 条

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