SARS-CoV-2 Impact on Red Blood Cell Morphology

被引：3

作者：

Kondratov, Kirill A. ^{[1
,2
,3
]}

Artamonov, Alexander A. ^{[2
]}

Mikhailovskii, Vladimir Yu. ^{[3
]}

Velmiskina, Anastasiya A. ^{[1
,3
]}

Mosenko, Sergey V. ^{[1
,3
]}

Grigoryev, Evgeniy A. ^{[3
]}

Anisenkova, Anna Yu. ^{[1
,3
]}

Nikitin, Yuri V. ^{[2
]}

Apalko, Svetlana V. ^{[1
,3
]}

Sushentseva, Natalya N. ^{[1
]}

Ivanov, Andrey M. ^{[2
]}

Scherbak, Sergey G. ^{[1
,3
]}

机构：

[1] City Hosp 40, St Petersburg 197706, Russia

[2] SM Kirov Mil Med Acad, St Petersburg 194044, Russia

[3] St Petersburg State Univ, St Petersburg 199034, Russia

来源：

BIOMEDICINES | 2023年 / 11卷 / 11期

关键词：

COVID-19; erythrocyte; red blood cells; cytokine storm; severe COVID-19; low-voltage scanning electron microscopy; erythrocyte size; DISTRIBUTION WIDTH; HYPOXIA; DIFFERENTIATION; METABOLISM; CASPASE-3;

D O I：

10.3390/biomedicines11112902

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Severe COVID-19 alters the biochemical and morphological characteristics of blood cells in a wide variety of ways. To date, however, the vast majority of research has been devoted to the study of leukocytes, while erythrocyte morphological changes have received significantly less attention. The aim of this research was to identify erythrocyte morphology abnormalities that occur in COVID-19, compare the number of different poikilocyte types, and measure erythrocyte sizes to provide data on size dispersion. Red blood cells obtained from 6 control donors (800-2200 cells per donor) and 5 COVID-19 patients (800-1900 cells per patient) were examined using low-voltage scanning electron microscopy. We did not discover any forms of erythrocyte morphology abnormalities that would be specific to COVID-19. Among COVID-19 patients, we observed an increase in the number of acanthocytes (p = 0.01) and a decrease in the number of spherocytes (p = 0.03). In addition, our research demonstrates that COVID-19 causes an increase in the median (p = 0.004) and interquartile range (p = 0.009) when assessing erythrocyte size. The limitation of our study is a small number of participants.

引用

页数：12

共 52 条

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