Influence of Drying Technique on Physicochemical Properties of Synthetic Hydroxyapatite and Its Potential Use as a Drug Carrier

被引:4
作者
Niziolek, Karina [1 ]
Slota, Dagmara [1 ]
Sadlik, Julia [1 ]
Lachut, Emilia [1 ]
Florkiewicz, Wioletta [1 ]
Sobczak-Kupiec, Agnieszka [1 ]
机构
[1] Cracow Univ Technol, Fac Mat Engn & Phys, Dept Mat Sci, 37 Jana Pawła II Av, PL-31864 Krakow, Poland
关键词
ceramic; hydroxyapatite; drug delivery system; clindamycin; MORPHOLOGY; DELIVERY; FTIR; XRD;
D O I
10.3390/ma16196431
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Naturally occurring hydroxyapatite (HA) is the mineral phase of bone tissue. It is characterized by its bioactivity toward stimulating bone cells to proliferate and thus form new apatite layers. For this reason, it is a material commonly used in implantology for filling defects or covering implants (such as endoprostheses). There are several methods to obtain synthetic HA, and by controlling parameters such as temperature, pressure or the drying process, physicochemical parameters of the final powder can be affected. In the present study, HA was obtained by wet precipitation technique and subjected to two different drying methods, determining whether this parameter significantly affects the properties of the final material obtained. Analyzed Fourier-transform infrared spectroscopy (FT-IR) confirmed the presence of functional groups typical for HA. X-ray diffraction analysis (XRD) demonstrated that the materials are partially amorphous; however, the only phase was identified in HA. Scanning electron microscopy (SEM) was used to evaluate the surface morphology and the density, and average grain diameter was measured. Furthermore, HA powders were subjected to modification with the antibiotic clindamycin to determine the potential for use as a carrier for the active substance. The release rate of the drug was determined by high-performance liquid chromatography (HPLC). The differences in the characteristics of the powders were relatively small; however, they affected the rate of drug release from the material as well as the shape of the grains. The method of drying the powders was shown to affect the shape of the grains, as well as the porosity of the sinters prepared from it. A higher amount of clindamycin released into PBS was observed in material with more pores. The materials have demonstrated the potential to be used as a carrier for the active substance; however, further biological, as well as physicochemical, analysis is required.
引用
收藏
页数:12
相关论文
共 52 条
  • [1] Experimental data on the characterization of hydroxyapatite synthesized from biowastes
    Abifarin, J. K.
    Obada, D. O.
    Dauda, E. T.
    Dodoo-Arhin, D.
    [J]. DATA IN BRIEF, 2019, 26
  • [2] Clindamycin and dentistry
    Addy, LD
    Martin, MV
    [J]. BRITISH DENTAL JOURNAL, 2005, 199 (01) : 23 - 26
  • [3] Controlled Drug Delivery Systems: Current Status and Future Directions
    Adepu, Shivakalyani
    Ramakrishna, Seeram
    [J]. MOLECULES, 2021, 26 (19):
  • [4] Hydroxyapatite ceramics prepared from two natural sources by direct thermal conversion: From material processing to mechanical measurements
    Akpan, E. S.
    Dauda, M.
    Kuburi, L. S.
    Obada, D. O.
    Bansod, N. D.
    Dodoo-Arhin, D.
    [J]. MATERIALS TODAY-PROCEEDINGS, 2021, 38 : 2291 - 2294
  • [5] The effect of preoperative clindamycin in reducing early oral implant failure: a randomised placebo-controlled clinical trial
    Arrieta, Gorka Santamaria
    Sanchez, Fabio Rodriguez
    Rodriguez-Andres, Carlos
    Barbier, Luis
    Arteagoitia, Iciar
    [J]. CLINICAL ORAL INVESTIGATIONS, 2023, 27 (03) : 1113 - 1122
  • [6] Is clindamycin effective in preventing infectious complications after oral surgery? Systematic review and meta-analysis of randomized controlled trials
    Arteagoitia, Iciar
    Sanchez, Fabio Rodriguez
    Figueras, Amaia
    Arroyo-Lamas, Nagore
    [J]. CLINICAL ORAL INVESTIGATIONS, 2022, 26 (06) : 4467 - 4478
  • [7] Adsorption/desorption study of antibiotic and anti-inflammatory drugs onto bioactive hydroxyapatite nano-rods
    Benedini, Luciano
    Placente, Damian
    Ruso, Juan
    Messina, Paula
    [J]. MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2019, 99 : 180 - 190
  • [8] Analysis of cell-biomaterial interaction through cellular bridge formation in the interface between hGMSCs and CaP bioceramics
    Benjumeda Wijnhoven, Isabel
    Vallejos, Raul
    Santibanez, Juan F.
    Millan, Carola
    Vivanco, Juan F.
    [J]. SCIENTIFIC REPORTS, 2020, 10 (01)
  • [9] Dendrimers for Drug Delivery
    Chauhan, Abhay Singh
    [J]. MOLECULES, 2018, 23 (04):
  • [10] DHAWAN VK, 1982, REV INFECT DIS, V4, P1133