Prognostic impact of MYD88 and TP53 mutations in diffuse large B Cell lymphoma

被引:5
作者
Ebid, Osama Abd El Hameed [1 ]
El Arab, Lobna R. Ezz [1 ]
Saad, Amr S. [1 ]
El Din, Mai Ezz [1 ]
Mostafa, Nermeen [1 ]
Swellam, Menha [2 ,3 ]
机构
[1] Ain Shams Univ, Fac Med, Clin Oncol Dept, Cairo, Egypt
[2] Natl Res Ctr, Biotechnol Res Inst, Biochem Dept, High Throughput Mol & Genet Technol Lab, Dokki 12622, Giza, Egypt
[3] Natl Res Ctr, Ctr Excellence, Dokki 12622, Giza, Egypt
关键词
MYD88; TP53; DLBCL; Prognosis; Response; NON-HODGKIN-LYMPHOMA; P53; GENE-MUTATIONS; L265P MUTATION; POOR SURVIVAL; EXPRESSION; CLASSIFICATION; RECOMMENDATIONS; FREQUENCY; RITUXIMAB; FEATURES;
D O I
10.1007/s00277-023-05420-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Diffuse large B cell lymphoma (DLBCL) is the most common subtype of lymphoma. It is a highly heterogeneous lymphoid neoplasm, with variations in gene expression profiles and genetic alterations. MYD88 and TP53 genes are common to be expressed and mutated in DLBCL patients with controversy regarding their role in prognosis and survival. This study aims to determine the predictive and prognostic role of MYD88 and TP53 gene mutation in DLBCL. A prospective cohort study was conducted on 50 patients who were diagnosed with DLBCL and 30 healthy individuals to assess the sensitivity and specificity of MYD88 and TP53 genetic mutations. MYD88 and TP53 gene mutations were more sensitive, specific, and accurate in predicting overall mortality and disease progression in comparison with the international prognostic index. Mutant MYD88 and TP53 showed their prognostic importance for worse objective response rates and survival outcomes. Both mutant MYD88 and TP53 were associated with worse ORR. There was a significant statistical difference for both MYD88 and TP53 with regard to 2-year PFS and 2-year OS rate. Hence, both mutant MYD88 and TP53 can be used in predicting disease progression and overall mortality.
引用
收藏
页码:3477 / 3488
页数:12
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