New Glycosylated Flavone and Anthraquinone from Cassia notabilis Randell.: Antidiabetic, Anti-inflammatory and Analgesic Activity Evaluation

The phytochemical investigation of the leaves of Cassia notabilis Randell. revealed the isolation of two new glycosides, identified as 6-methoxyapigenin-4`-methyl ether 7-O-& alpha;-L-rhamnopyranoside-8-C-& beta;-D-glucopyranoside (1) and 1,7,8-trihydroxyanthraquinone 3-O-& beta;-D-glucopyranoside (7), along with apigenin 7-O- & beta;-D-glucpyranosyl-(1 & RARR;6)-& beta;-D- glucopyranoside(2), acacetin 7-O-& alpha;-L-rhamnopyranoside (3), luteolin 7-O- & beta;-D-glucpyranosyl-(1 & RARR;6)-& beta;-D- glucopyranoside(4), luteolin 7-O- & beta;-D-glucpyranoside (5), diosmetin 7-O-& alpha;-L-rhamnopyranoside (6). The structures of the isolated compounds were established by chromatographic and spectroscopic evidences. Pharmacological studies showed that the three doses of 70% aqueous methanolic extract of C. notabilis leaves (125, 250 and 500 mg/kg) have antidiabetic, analgesic, anti-inflammatory and antioxidant activity.