New Glycosylated Flavone and Anthraquinone from Cassia notabilis Randell.: Antidiabetic, Anti-inflammatory and Analgesic Activity Evaluation

被引：0
|
作者：
Nassar, Mahmoud I. [1 ]
Taher, Rehab F. [1 ]
El-Toumy, Sayed A. [2 ]
El-Hawary, Seham S. [3 ]
Ahmed, Rania F. [4 ]
El-Khrisy, Ezzel-Din A. [1 ]
机构：
[1] Natl Res Ctr, Dept Nat Cpds Chem, Giza 12622, Egypt
[2] Natl Res Ctr, Chem Tannins Dept, Giza 12622, Egypt
[3] Cairo Univ, Fac Pharm, Pharmacognosy Dept, Cairo, Egypt
[4] Natl Res Ctr, Pharmacol Dept, Giza 12622, Egypt
来源：
EGYPTIAN JOURNAL OF CHEMISTRY | 2023年 / 66卷 / 06期
关键词：
Cassia notabilis; flavonoids; antidiabetic; anti-inflammatory; analgesic; antioxidant; ANTIOXIDANT ACTIVITY; GLYCOSIDES; TORA;
D O I：
10.21608/EJCHEM.2022.178935.7271
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The phytochemical investigation of the leaves of Cassia notabilis Randell. revealed the isolation of two new glycosides, identified as 6-methoxyapigenin-4`-methyl ether 7-O-& alpha;-L-rhamnopyranoside-8-C-& beta;-D-glucopyranoside (1) and 1,7,8-trihydroxyanthraquinone 3-O-& beta;-D-glucopyranoside (7), along with apigenin 7-O- & beta;-D-glucpyranosyl-(1 & RARR;6)-& beta;-D- glucopyranoside(2), acacetin 7-O-& alpha;-L-rhamnopyranoside (3), luteolin 7-O- & beta;-D-glucpyranosyl-(1 & RARR;6)-& beta;-D- glucopyranoside(4), luteolin 7-O- & beta;-D-glucpyranoside (5), diosmetin 7-O-& alpha;-L-rhamnopyranoside (6). The structures of the isolated compounds were established by chromatographic and spectroscopic evidences. Pharmacological studies showed that the three doses of 70% aqueous methanolic extract of C. notabilis leaves (125, 250 and 500 mg/kg) have antidiabetic, analgesic, anti-inflammatory and antioxidant activity.
引用
收藏
页码：411 / 418
页数：8
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