Facile access to sodium arylsulfinates via nucleophilic C-S bond cleavage of 2-(arylsulfonyl)pyrimidines

被引：0
作者：
Kwon, Yujeong [1 ]
Lee, Jihong [1 ]
Lee, Dong-Chan [2 ]
Sohn, Jeong-Hun [1 ]
机构：
[1] Chungnam Natl Univ, Coll Nat Sci, Dept Chem, Dajeon 34134, South Korea
[2] Univ Nevada, Dept Chem & Biochem, Las Vegas, NV 89154 USA
来源：
TETRAHEDRON LETTERS | 2023年 / 123卷
基金：
新加坡国家研究基金会;
关键词：
Sulfinate; C -S bond cleavage; Pyrimidinyl sulfone; Organosulfur; C -S cross -coupling; SULFUR-DIOXIDE; ONE-POT; SULFINATE DERIVATIVES; CONVENIENT SYNTHESIS; CATALYZED SYNTHESIS; COUPLING REACTIONS; BORONIC ACIDS; ALKYL-HALIDES; ARYL; SULFONES;
D O I：
10.1016/j.tetlet.2023.154556
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Described is a route to sodium arylsulfinates in their pure forms via the three-step sequence including the Cu-catalyzed C-S cross-coupling of 4,5,6-trimethylpyrimidine-2(1H)-thione with aryl iodides followed by oxidation to yield the corresponding pyrimidinyl sulfones, which were converted to the desired sodium sulfinates by the nucleophilic C-S cleavage using NaOMe and trituration for isolation and purification. & COPY; 2023 Elsevier Ltd. All rights reserved.
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页数：5
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