Pancreatic Cancer Biomarkers: Oncogenic Mutations, Tissue and Liquid Biopsies, and Radiomics-A Review

被引：24

作者：

Amaral, Maria Joao ^{[1
,2
]}

Oliveira, Rui Caetano ^{[3
,4
,5
]}

Donato, Paulo ^{[2
,6
]}

Tralhao, Jose Guilherme ^{[1
,2
,5
,7
]}

机构：

[1] Univ Coimbra, Ctr Hospitalar, Gen Surg Dept, Praceta Mota Pinto, P-3000075 Coimbra, Portugal

[2] Univ Coimbra, Fac Med, Coimbra, Portugal

[3] Ctr Hosp & Univ Coimbra, Pathol Dept, Coimbra, Portugal

[4] Clin Acad Ctr Coimbra CACC, Coimbra, Portugal

[5] Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med, Area Environm Genet & Oncobiol CIMAGO, Coimbra, Portugal

[6] Ctr Hosp & Univ Coimbra, Radiol Dept, Coimbra, Portugal

[7] Univ Coimbra, Biophys Inst, Coimbra, Portugal

来源：

DIGESTIVE DISEASES AND SCIENCES | 2023年 / 68卷 / 07期

关键词：

Pancreatic cancer; Biomarkers; Oncogenic mutations; Liquid biopsies; CIRCULATING TUMOR-CELLS; QUANTITATIVE IMAGING BIOMARKERS; PAPILLARY MUCINOUS NEOPLASMS; DUCTAL ADENOCARCINOMA; PROGNOSTIC VALUE; PROMOTER HYPERMETHYLATION; DIFFERENTIAL-DIAGNOSIS; CLINICAL UTILITY; BRCA MUTATIONS; FREE DNA;

D O I：

10.1007/s10620-023-07904-6

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pancreatic cancer is one of the most fatal malignancies, as approximately 80% of patients are at advanced stages by the time of diagnosis. The main reason for the poor overall survival is late diagnosis that is partially due to the lack of tools for early-stage detection. In addition, there are several challenges in evaluating response to treatment and predicting prognosis. In this article, we do a review of the most common pancreatic cancer biomarkers with emphasis in new and promising approaches. Liquid biopsies seem to have important clinical applications in early detection, screening, prognosis, and longitudinal monitoring of on-treatment patients. Together with biomarkers in imaging, can represent valuable alternative non-invasive tools in order to achieve a more effective management of pancreatic cancer patients.

引用

页码：2811 / 2823

页数：13

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